Autoimmune hepatitis and acquired partial lipodystrophy
Bakewell, Christopher Dayasiri, Kavinda Brown, Rachel M Rodrigues, Astor Williams, Rachel Anand, Geetha Gupte, Girish L
Bakewell, Christopher
Dayasiri, Kavinda
Brown, Rachel M
Rodrigues, Astor
Williams, Rachel
Anand, Geetha
Gupte, Girish L
Abstract
The lipodystrophies are an extremely rare group of metabolic conditions which are categorised based on their pathogenesis and phenotype. While primarily known for the striking loss of subcutaneous adipose tissue which they induce, they may also be associated with significant liver injury. In most cases, this results from the secondary deposition of lipid within hepatic parenchyma and is seen predominantly in generalised lipodystrophy. More rarely, patients may develop autoimmune hepatitis. We report a rare case of a 17-month-old boy who developed features of acquired partial lipodystrophy in association with anti-LKM1-positive autoimmune hepatitis following initial presentation with a Henoch-Schönlein purpura-like illness. We describe his challenging path to diagnosis and discuss his ongoing management in an effort to further our understanding of this rare but significant association. This report highlights the need for close clinical observation and a high index of suspicion for recognising early features of lipodystrophy.
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Date
2021-05-14
Type
Article
Subject
Paediatrics, Clinical pathology
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Citation
Bakewell C, Dayasiri K, Brown RM, Rodrigues A, Williams R, Anand G, Gupte GL. Autoimmune hepatitis and acquired partial lipodystrophy. Frontline Gastroenterol. 2021 May 14;13(2):175-177. doi: 10.1136/flgastro-2021-101824
Journal / Source Title
Frontline Gastroenterology
DOI
10.1136/flgastro-2021-101824
PMID
35300473
Publisher
BMJ Publishing Group
Publisher’s URL
http://fg.bmj.com/