The impact of advanced patient age in liver transplantation: a European Liver Transplant Registry propensity-score matching study.
Abstract
Background: The futility of liver transplantation in elderly recipients remains under debate in the HCV eradication era.
Methods: The aim was to assess the effect of older age on outcome after liver transplantation. We used the ELTR to study the relationship between recipient age and post-transplant outcome. Young and elderly recipients were compared using a PSM method.
Results: A total of 10,172 cases were analysed. Recipient age >65 years was identified as an independent risk factor associated with reduced patient survival (HR:1.42 95%CI:1.23-1.65,p < 0.001). After PSM, 2124 patients were matched, and the same association was found between elderly recipients and patient survival and graft survival (p < 0.001). As hepatocellular carcinoma and alcoholic cirrhosis were independent prognostic factors for patient and graft survival a propensity score-matching was performed for each. Patient and graft survival were significantly worse (p < 0.05) in the alcoholic cirrhosis elderly group. However, patient and graft survival in the hepatocellular carcinoma cohort were similar (p > 0.05) between groups.
Conclusion: Liver transplantation is an acceptable and safe curative option for elderly transplant candidates, with worse long-term outcomes compare to young candidates. The underlying liver disease for liver transplantation has a significant impact on the selection of elderly patients.
Author
Gómez-Gavara, Concepción
Lim, Chetana
Adam, René
Zieniewicz, Krzysztof
Karam, Vincent
Mirza, Darius
Heneghan, Michael
Pirenne, Jacques
Cherqui, Daniel
Oniscu, Gabriel
Watson, Christopher
Schneeberger, Stefan
Boudjema, Karim
Fondevila, Constantino
Pratschke, Johann
Salloum, Chady
Esposito, Francesco
Esono, Daniel
Lahat, Eylon
Feray, Cyrille
Azoulay, Daniel
Lim, Chetana
Adam, René
Zieniewicz, Krzysztof
Karam, Vincent
Mirza, Darius
Heneghan, Michael
Pirenne, Jacques
Cherqui, Daniel
Oniscu, Gabriel
Watson, Christopher
Schneeberger, Stefan
Boudjema, Karim
Fondevila, Constantino
Pratschke, Johann
Salloum, Chady
Esposito, Francesco
Esono, Daniel
Lahat, Eylon
Feray, Cyrille
Azoulay, Daniel
Citations
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Date
2021-11-17
Type
Article
Subject
Gastroenterology, Surgery
Collections
Citation
Gómez-Gavara C, Lim C, Adam R, Zieniewicz K, Karam V, Mirza D, Heneghan M, Pirenne J, Cherqui D, Oniscu G, Watson C, Schneeberger S, Boudjema K, Fondevila C, Pratschke J, Salloum C, Esposito F, Esono D, Lahat E, Feray C, Azoulay D; all the ELTR centers (www.eltr.org) for the European Liver and Intestine Transplant Association (ELITA). The impact of advanced patient age in liver transplantation: a European Liver Transplant Registry propensity-score matching study. HPB (Oxford). 2022 Jun;24(6):974-985. doi: 10.1016/j.hpb.2021.11.007. Epub 2021 Nov 17
Journal / Source Title
HPB
DOI
10.1016/j.hpb.2021.11.007
PMID
34872865
Publisher
Elsevier
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1477-2574