Chronic intestinal failure in children: an international multicenter cross-sectional survey.
Abstract
Background: The European Society for Clinical Nutrition and Metabolism database for chronic intestinal failure (CIF) was analyzed to investigate factors associated with nutritional status and the intravenous supplementation (IVS) dependency in children. Methods: Data collected: demographics, CIF mechanism, home parenteral nutrition program, z-scores of weight-for-age (WFA), length or height-for-age (LFA/HFA), and body mass index-for-age (BMI-FA). IVS dependency was calculated as the ratio of daily total IVS energy over estimated resting energy expenditure (%IVSE/REE). Results: Five hundred and fifty-eight patients were included, 57.2% of whom were male. CIF mechanisms at age 1−4 and 14−18 years, respectively: SBS 63.3%, 37.9%; dysmotility or mucosal disease: 36.7%, 62.1%. One-third had WFA and/or LFA/HFA z-scores < −2. One-third had %IVSE/REE > 125%. Multivariate analysis showed that mechanism of CIF was associated with WFA and/or LFA/HFA z-scores (negatively with mucosal disease) and %IVSE/REE (higher for dysmotility and lower in SBS with colon in continuity), while z-scores were negatively associated with %IVSE/REE. Conclusions: The main mechanism of CIF at young age was short bowel syndrome (SBS), whereas most patients facing adulthood had intestinal dysmotility or mucosal disease. One-third were underweight or stunted and had high IVS dependency. Considering that IVS dependency was associated with both CIF mechanisms and nutritional status, IVS dependency is suggested as a potential marker for CIF severity in children.
Author
Lezo, Antonella
Diamanti, Antonella
Marinier, Evelyne M
Tabbers, Merit
Guz-Mark, Anat
Gandullia, Paolo
Spagnuolo, Maria I
Protheroe, Sue
Peretti, Noel
Merras-Salmio, Laura
Hulst, Jessie M
Kolaček, Sanja
Ee, Looi C
Lawrence, Joanna
Hind, Jonathan
D'Antiga, Lorenzo
Verlato, Giovanna
Pukite, Ieva
Di Leo, Grazia
Vanuytsel, Tim
Doitchinova-Simeonova, Maryana K
Ellegard, Lars
Masconale, Luisa
Maíz-Jiménez, María
Cooper, Sheldon C
Brillanti, Giorgia
Nardi, Elena
Sasdelli, Anna S
Lal, Simon
Pironi, Loris
Diamanti, Antonella
Marinier, Evelyne M
Tabbers, Merit
Guz-Mark, Anat
Gandullia, Paolo
Spagnuolo, Maria I
Protheroe, Sue
Peretti, Noel
Merras-Salmio, Laura
Hulst, Jessie M
Kolaček, Sanja
Ee, Looi C
Lawrence, Joanna
Hind, Jonathan
D'Antiga, Lorenzo
Verlato, Giovanna
Pukite, Ieva
Di Leo, Grazia
Vanuytsel, Tim
Doitchinova-Simeonova, Maryana K
Ellegard, Lars
Masconale, Luisa
Maíz-Jiménez, María
Cooper, Sheldon C
Brillanti, Giorgia
Nardi, Elena
Sasdelli, Anna S
Lal, Simon
Pironi, Loris
Citations
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Date
2022-04-30
Type
Article
Subject
Diet & nutrition, Gastroenterology, Endocrinology
Citation
Lezo A, Diamanti A, Marinier EM, Tabbers M, Guz-Mark A, Gandullia P, Spagnuolo MI, Protheroe S, Peretti N, Merras-Salmio L, Hulst JM, Kolaček S, Ee LC, Lawrence J, Hind J, D'Antiga L, Verlato G, Pukite I, Di Leo G, Vanuytsel T, Doitchinova-Simeonova MK, Ellegard L, Masconale L, Maíz-Jiménez M, Cooper SC, Brillanti G, Nardi E, Sasdelli AS, Lal S, Pironi L. Chronic Intestinal Failure in Children: An International Multicenter Cross-Sectional Survey. Nutrients. 2022 Apr 30;14(9):1889. doi: 10.3390/nu14091889
Journal / Source Title
Nutrients
DOI
10.3390/nu14091889
PMID
35565856
Publisher
MDPI Publishing
Publisher’s URL
http://www.mdpi.com/journal/nutrients