Role of microbiota and microbiota-derived short-chain fatty acids in PDAC.
Temel, Hülya Yılmaz Kaymak, Öznur Kaplan, Seren Bahcivanci, Basak Gkoutos, Georgios V Acharjee, Animesh
Temel, Hülya Yılmaz
Kaymak, Öznur
Kaplan, Seren
Bahcivanci, Basak
Gkoutos, Georgios V
Acharjee, Animesh
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive lethal diseases among other cancer types. Gut microbiome and its metabolic regulation play a crucial role in PDAC. Metabolic regulation in the gut is a complex process that involves microbiome and microbiome-derived short-chain fatty acids (SCFAs). SCFAs regulate inflammation, as well as lipid and glucose metabolism, through different pathways. This review aims to summarize recent developments in PDAC in the context of gut and oral microbiota and their associations with short-chain fatty acid (SCFA). In addition to this, we discuss possible therapeutic applications using microbiota in PDAC.
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Date
2022-10-07
Type
Article
Subject
Human physiology, Biochemistry
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Citation
Temel HY, Kaymak Ö, Kaplan S, Bahcivanci B, Gkoutos GV, Acharjee A. Role of microbiota and microbiota-derived short-chain fatty acids in PDAC. Cancer Med. 2023 Mar;12(5):5661-5675. doi: 10.1002/cam4.5323. Epub 2022 Oct 7
Journal / Source Title
Cancer Medicine
DOI
10.1002/cam4.5323
PMID
36205023
Publisher
Wiley
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)2045-7634
https://www.ncbi.nlm.nih.gov/pmc/journals/1974/
https://www.ncbi.nlm.nih.gov/pmc/journals/1974/