Clinical outcomes of observed and treated acute posterior multifocal placoid pigment epitheliopathy and relentless placoid chorioretinitis
Steptoe, Paul J Pearce, Ian Beare, Nicholas A V Sreekantham, Sreekanth Mohammed, Bashar R Denniston, Alastair K Murray, Philip I
Steptoe, Paul J
Pearce, Ian
Beare, Nicholas A V
Sreekantham, Sreekanth
Mohammed, Bashar R
Denniston, Alastair K
Murray, Philip I
Abstract
Purpose: To assess the efficacy of treatment on acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and relentless placoid chorioretinopathy (RPC). Methods: Cases were identified from three UK uveitis centers. Retrospective analysis of visual acuity recovery; OCT structural outcomes; and retinal lesion quantification in observed and treated cases of APMPPE/RPC. Results: There were nine APMPPE and three RPC cases. Out of 12 patients, six were female. Median age: 26.5 years (range, 20-57 years). Four cases (six eyes) were observed, and eight cases (15 eyes) received corticosteroids ± immunosuppression. 4/4 observed and 6/10 treated foveal involving eyes regained 0.00 LogMAR vision. Observed lesions achieved more favorable anatomical outcomes. New lesions post-presentation developed in 1/6 (16%) observed eye versus 10/15 (66%) treated eyes. In three cases, a delayed, rebound lesion occurrence was observed post-high-dose corticosteroids. Conclusions: While subject to potential treatment bias, in this small case series, natural history alone appears non-inferior to corticosteroid treatment.
Affiliations
University of Edinburgh; Princess Alexandra Eye Pavilion; Liverpool University Hospitals NHS Foundation Trust; Sandwell and West Birmingham NHS Trust; et al.
Citations
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Date
2023-05-03
Type
Article
Subject
Collections
Citation
Steptoe PJ, Pearce I, Beare NAV, Sreekantham S, Mohammed BR, Barry RJ, Denniston AK, Murray PI. Clinical Outcomes of Observed and Treated Acute Posterior Multifocal Placoid Pigment Epitheliopathy and Relentless Placoid Chorioretinitis. Ocul Immunol Inflamm. 2023 May 3:1-7. doi: 10.1080/09273948.2023.2195934.