Complex enterally tube-fed community patients display stable tolerance, improved compliance and better achieve energy and protein targets with a high-energy, high-protein peptide-based enteral tube feed: results from a multi-centre pilot study
Green, Benjamin Sorensen, Katy Phillips, Mary Green, Lisa Watson, Rachel McCallum, Adrienne Brook, Sarah Oldham, Siobhan Barry, Michelle Tomlinson, Lyndsey
Green, Benjamin
Sorensen, Katy
Phillips, Mary
Green, Lisa
Watson, Rachel
McCallum, Adrienne
Brook, Sarah
Oldham, Siobhan
Barry, Michelle
Tomlinson, Lyndsey
Abstract
This pilot study evaluated a high-energy, high-protein, peptide-based, (medium-chain triglycerides) MCT-containing enteral tube feed (Nutrison Peptisorb Plus HEHP®, Nutricia Ltd., Trowbridge, BA14 0XQ, UK.) containing 1.5 kcal/mL and 7.5 g protein/100 mL. Fifteen community-based, enterally tube-fed adults (42 (SD 16.3) years) received the intervention feed daily for 28 days, with gastrointestinal tolerance, compliance and nutrient intake assessed at baseline and after the intervention period. Incidence and intensity of constipation (p = 0.496), nausea (p = 1.000), abdominal pain (p = 0.366) and bloating (p = 0.250) remained statistically unchanged, yet the incidence and intensity of diarrhoea improved significantly after receiving the intervention feed (Z = -2.271, p = 0.023). Compliance with the intervention feed was significantly greater compared to the patient's baseline regimens (99% vs. 87%, p = 0.038). Compared to baseline, use of the intervention feed enabled patients to significantly increase total energy (1676 kcal/day (SD 449) to 1884 kcal/day (SD 537), p = 0.039) and protein intake (73 g/day (SD 17) to 89 g/day (SD 23), p = 0.001), allowing patients to better achieve energy (from 88% to 99%, p = 0.038) and protein (from 101% to 121%, p < 0.001) requirements. This pilot study demonstrates that a high-energy, high-protein, peptide-based, MCT-containing enteral tube feed maintains gastrointestinal tolerance and improves compliance, energy and protein intake in complex, enterally tube-fed, community-based adult patients, though more work is recommended to confirm this.
MIDER Authors
Affiliations
Nutricia; Royal Surrey County Hospital NHS Foundation Trust; Calderdale and Huddersfield NHS Foundation Trust; Gloucestershire Hospitals NHS Foundation Trust; Somerset NHS Foundation Trust; University Hospitals Bristol and Weston NHS Foundation Trust; Aneurin Bevan University Health Board; North Tees and Hartlepool NHS Foundation Trust; Northumbria Healthcare NHS Foundation Trust; University Hospitals of Derby and Burton NHS Foundation Trust; University Hospitals Birmingham NHS Foundation Trust; NHS Greater Glasgow and Clyde; University of Southampton
Date
2020-11-18
Type
Article
Collections
Citation
Green B, Sorensen K, Phillips M, Green L, Watson R, McCallum A, Brook S, Oldham S, Barry M, Tomlinson L, Williams A, Crease S, Wills C, Talbot R, Thomas R, Barker J, Owen A, Davies J, Robinson C, Lumsdon A, Morris S, McMurray C, Cunningham N, Miller L, Day C, Stanley K, Price S, Duff S, Julian A, Thomas J, Fleming CA, Hubbard G, Stratton R. Complex Enterally Tube-Fed Community Patients Display Stable Tolerance, Improved Compliance and Better Achieve Energy and Protein Targets with a High-Energy, High-Protein Peptide-Based Enteral Tube Feed: Results from a Multi-Centre Pilot Study. Nutrients. 2020 Nov 18;12(11):3538. doi: 10.3390/nu12113538.