Contour improvements in skin graft reconstruction of nasal defects
McNiven, Neil David Butler, Jemma Anari, Shahram
McNiven, Neil David
Butler, Jemma
Anari, Shahram
Abstract
Objectives: This study aimed to describe a one-stage technique for nasal skin defect reconstruction using an oxidised regenerated cellulose/collagen matrix (Promogran™) to enhance contour and graft survival.
Methods: Following excision of a skin lesion, Promogran™ is cut to size, placed in the wound bed to restore contour and provide bulk, saturated with blood and covered with a full-thickness skin graft.
Results: The technique improves cosmesis and enables graft survival over avascular structures, including exposed bone and cartilage. Promogran™ exerts wound-healing effects such as matrix metalloprotease inhibition, regulation of growth factors and cytokines, free-radical scavenging and fibroblast proliferation.
Conclusion: This simple, one-stage approach offers an alternative to complex or multistage reconstruction for patients unsuitable for, or preferring to avoid, more invasive procedures.
MIDER Authors
Affiliations
University Hospitals Birmingham NHS Foundation Trust; Worcestershire Acute Hospitals NHS Trust
Date
2025-12-17
Type
Article
Collections
Citation
McNiven ND, Butler J, Anari S. Contour improvements in skin graft reconstruction of nasal defects. J Laryngol Otol. 2026 Feb;140(2):225-229. doi: 10.1017/S0022215125104040.