Myelin oligodendrocyte glycoprotein antibody-associated optic neuritis-a review.
Kaushik, Megha Burdon, Michael A
Kaushik, Megha
Burdon, Michael A
Abstract
Our understanding of demyelinating optic neuritis has substantially evolved over the past 2 decades. With advancements in serological testing, antibodies against myelin oligodendrocyte glycoprotein (MOG) have been recently discovered in a distinct subset of demyelinating neuroinflammatory disease. Although MOG-immunoglobulin G (IgG)-associated disorder (MOGAD) has previously been seen as a component of neuromyelitis optica spectrum disorder (NMOSD), evidence increasingly suggests that it should be distinguished as a separate condition. The distinction of MOGAD from aquaporin-4 IgG NMOSD is imperative as treatment plans need to be tailored to its unique disease course and prognosis. The purpose of this review is to explore the nature and outcomes of MOGAD optic neuritis to help guide acute and long-term immunosuppressive treatment decisions.
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Date
2021-12-01
Type
Article
Subject
Neurology
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Citation
Kaushik M, Burdon MA. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis-A Review. J Neuroophthalmol. 2021 Dec 1;41(4):e786-e795. doi: 10.1097/WNO.0000000000001234
Journal / Source Title
Journal of Neuro-Ophthalmology
DOI
10.1097/WNO.0000000000001234
PMID
33870945
Publisher
Lippincott Williams & Wilkins