Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study.
Osailan AM Metsios GS Duda JL Kitas GD Veldhuijzen van Zanten JJCS Elnaggar RK
Osailan AM
Metsios GS
Duda JL
Kitas GD
Veldhuijzen van Zanten JJCS
Elnaggar RK
Abstract
Individuals with rheumatoid arthritis (RA) are at a high risk of cardiovascular diseases (CVD). A reduced chronotropic response (CR), which produces exercise intolerance, is known to be a contributing factor to CVD and mortality. Studies have shown that patients with RA have a reduced CR. However, knowledge of CR-related factors in patients with RA is limited. This study aimed to explore CR-related factors, including CVD risk factors, inflammatory markers, and cardiorespiratory fitness (VO 2PEAK ). A total of 106 RA patients underwent a treadmill test, heart rate monitoring, and various assessments, including serological CVD risk factors, inflammatory markers, and VO 2PEAK . Results: A total of 34% of participants demonstrated a reduced CR (?80%). Body mass index, HOMA, hsCRP, and fibrinogen were inversely related to CR, while HDL, QUICKi, VO 2PEAK , and RER exhibited a positive association. HDL and VO 2PEAK emerged as independent CR-related factors in regression analysis. Conclusions: The current findings suggest that reduced CR in RA is associated with several CVD risk factors, inflammatory markers, and cardiorespiratory fitness. Future studies should investigate the effects of controlling these associated variables on CR in patients with RA.
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Date
23/11/2023
Type
Article
Subject
Cardiology
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Citation
Osailan AM, Metsios GS, Duda JL, Kitas GD, Veldhuijzen van Zanten JJCS, Elnaggar RK. Chronotropic Response and Risk Factors for Cardiovascular Disease in Patients with Rheumatoid Arthritis: A Cross-Sectional Study. J Clin Med. 2023 Nov 23;12(23):7256. doi: 10.3390/jcm12237256. PMID: 38068312; PMCID: PMC10707339.
Journal / Source Title
Journal of Clinical Medicine
DOI
10.3390/jcm12237256
PMID
38068312
Publisher
MDPI AG