Exacerbations of lung disease in Alpha-1 antitrypsin deficiency.
Smith, Daniel J Ellis, Paul R Turner, Alice M
Smith, Daniel J
Ellis, Paul R
Turner, Alice M
Abstract
Alpha-1 antitrypsin deficiency (AATD) is an important risk factor for development of chronic obstructive pulmonary disease (COPD). Patients with AATD classically develop a different pattern of lung disease from those with usual COPD, decline faster and exhibit a range of differences in pathogenesis, all of which may be relevant to phenotype and/or impact of exacerbations. There are a number of definitions of exacerbation, with the main features being worsening of symptoms over at least 2 days, which may be associated with a change in treatment. In this article we review the literature surrounding exacerbations in AATD, focusing, in particular, on ways in which they may differ from such events in usual COPD, and the potential impact on clinical management.
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Date
2021-01
Type
Article
Subject
Respiratory medicine
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Citation
Smith DJ, Ellis PR, Turner AM. Exacerbations of Lung Disease in Alpha-1 Antitrypsin Deficiency. Chronic Obstr Pulm Dis. 2021 Jan;8(1):162–76. doi: 10.15326/jcopdf.2020.0173
Journal / Source Title
Chronic Obstructive Pulmonary Diseases (Miami, Fla.)
DOI
10.15326/jcopdf.2020.0173
PMID
33238089
Publisher
COPD Foundation
Publisher’s URL
http://journal.copdfoundation.org