The effect of extended hemodialysis on nutritional parameters: a systematic review
Burton, James March, Daniel
Burton, James
March, Daniel
Abstract
Objective: This systematic review provides an up-to-date synthesis on the effects of extended hemodialysis on nutritional outcomes.
Design and methods: Ten databases were searched. Inclusion criteria were: randomised and non-randomised studies of extended hemodialysis (defined by > 15 h/week) with a comparator group which received conventional in-centre hemodialysis (usually ≤ 12 h per week). Outcomes of interest included lean body mass, protein and carbohydrate intake, body mass index, dry lean mass, water-soluble vitamin levels, serum levels of appetite hormones, and nutritional status as assessed by the PEW and SGA scoring tools.
Results: Five studies were eligible. All investigated extended nocturnal hemodialysis (one with the addition of short daily), three were in-centre and two were at home. Range of duration for the included studies was 2-18 months. These studies reported data on lean body mass, protein and carbohydrate intake, body mass index, dry lean mass and water-soluble vitamin levels. There was insufficient homogeneity between the studies to meta-analyse the data. Extended hemodialysis had no significant effects on any of the reported outcomes except for lean body mass, where a significant increase was found, and water-soluble vitamin levels, where deficiency was identified in one of the included studies.
Conclusion: There is currently no evidence to suggest that extended hemodialysis modalities impact nutritional parameters, although the quality of the available evidence is low.
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Date
2022-08-12
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Majlessi, A., Burton, J. O., & March, D. S. (2022). The effect of extended hemodialysis on nutritional parameters: a systematic review. Journal of nephrology, 35(8), 1985–1999. https://doi.org/10.1007/s40620-022-01395-w