Paraprotein-induced spurious hypercalcaemia: diagnostic pitfalls in two cases.
Abstract
This brief report describes 2 cases in which paraprotein caused spurious biochemistry results. In both cases standard laboratory measurements of calcium indicated the patients were hypercalcaemic and had significantly raised Vitamin D concentrations in serum. However, use of alternative measurements of calcium and vitamin D showed that these results were spurious. Clinicians looking after patients with significant paraprotein concentrations or other significant protein abnormalities should be aware of the possibility of assay interference when reviewing their biochemistry results. This awareness can be vital in avoiding unnecessary investigations or treatments, thus not only saving resources but also protecting patients from harm that may be caused by inappropriate therapies.
Date
2025-07-31
Type
Report
Subject
Clinical pathology, Haematology, Biochemistry, Endocrinology
Collections
Citation
Lorde N, Pratt G, Geberhiwot T, Ayuk J, Gittoes N. Paraprotein-induced spurious hypercalcaemia: diagnostic pitfalls in two cases. Eur J Endocrinol. 2025 Jul 31;193(2):K1-K4. doi: 10.1093/ejendo/lvaf151.
Journal / Source Title
European Journal of Endocrinology
DOI
10.1093/ejendo/lvaf151
PMID
40712044
Publisher
Oxford University Press
Publisher’s URL
https://academic.oup.com/ejendo/?login=false
https://eje.bioscientifica.com/
https://eje.bioscientifica.com/