Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres
Young, David Rahmany, Sohail Taylor, Deborah Davis, Emma Colwill, Michael Kalyanji Mehta, Sonia Campbell, Roisin Hazel, Karl Sethi-Arora, Karishma Ritchie, Susan
Young, David
Rahmany, Sohail
Taylor, Deborah
Davis, Emma
Colwill, Michael
Kalyanji Mehta, Sonia
Campbell, Roisin
Hazel, Karl
Sethi-Arora, Karishma
Ritchie, Susan
Abstract
Background: Filgotinib, an oral Janus kinase 1 preferential inhibitor, has been shown to be an effective treatment for ulcerative colitis (UC) in pre-registration studies. We aimed to describe the treatment population, effectiveness and safety of filgotinib in a real-world cohort of patients with UC.
Methods: A retrospective observational cohort evaluation was conducted across nine UK inflammatory bowel disease centres. Baseline demographic and clinical data, clinical disease activity scores, endoscopic activity indices, and biomarkers (C-reactive protein and faecal calprotectin) were collected at baseline, at 8–12 weeks after initiation (post-induction) and during maintenance (the most recent review) where available. Effectiveness outcomes were assessed in patients with combined clinical disease activity and objective evidence of inflammation at filgotinib initiation.
Results: Data were analysed for a total of 286 patients with a median follow-up time of 229 (IQR 113–324) days. The median age at filgotinib initiation was 38 (IQR 27–51) years, 64% were men and median disease duration was 5.1 (IQR 1.9–10.5) years; 56% had previous exposure to advanced therapies (biologics and small molecule) and 6% previously received tofacitinib. At the post-induction review, clinical response and remission were achieved in 65% and 51% of patients, respectively. There was a reduction in biomarkers and 78% of patients using corticosteroids at baseline were steroid-free. Persistence on filgotinib at 12 months was 66%. Adverse events were recorded in 30 patients with 8 patients discontinuing filgotinib as a result of an adverse event.
Conclusions: In a large real-world cohort of patients with UC, filgotinib appears to be effective and well-tolerated.
MIDER Authors
Date
2025-01-29
Type
Journal Article
Subject
Gastroenterology, Pharmacology
Collections
Citation
Young D, Rahmany S, Taylor D, Davis E, Colwill M, Kalyanji Mehta S, Campbell R, Hazel K, Sethi-Arora K, Ritchie S, Heinson AI, Moyses H, Bodger K, Johnston E, Hicks L, Dhar A, Limdi J, Cooney R, Seenan JP, Patel K, Walsh A, Cummings F. Real-world assessment of effectiveness and safety of filgotinib in 286 patients with ulcerative colitis in 9 UK centres. Drugs Context. 2025 Jan 29;14:2024-11-1. doi: 10.7573/dic.2024-11-1.
Journal / Source Title
Drugs in context
DOI
10.7573/dic.2024-11-1
PMID
39917051
Publisher
Bioexcel Publishing Ltd
Publisher’s URL
https://pmc.ncbi.nlm.nih.gov/journals/?term=101262187
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