COVID-19 infection in patients with intestinal failure: UK experience.
Allan, P J Ambrose, T Mountford, C Bond, A Donnellan, C Boyle, R Calvert, C Cernat, E Clarke, E Cooper, S C
Allan, P J
Ambrose, T
Mountford, C
Bond, A
Donnellan, C
Boyle, R
Calvert, C
Cernat, E
Clarke, E
Cooper, S C
Abstract
Background: The direct effect of the coronavirus disease 2019 (COVID-19) pandemic on patients with intestinal failure (IF) has not been described.
Methods: We conducted a nationwide study of UK IF centers to evaluate the infection rates, presentations, and outcomes in patients with types 2 and 3 IF.
Results: A total of 45 patients with IF contracted COVID-19 between March and August 2020; this included 26 of 2191 (1.2%) home parenteral nutrition (HPN)-dependent adults and 19 of 298 (6.4%) adults hospitalized with type 2 IF. The proportion of patients receiving nursing care for HPN administration was higher in those with community-acquired COVID-19 (66.7%) than the proportion in the entire HPN cohort (26.1%; P < .01). Two HPN-dependent and 1 hospitalized patient with type 2 IF died as a direct consequence of the virus (6.7% of 45 patients with types 2 or 3 infected).
Conclusion: This is the first study to describe the outcomes of COVID-19 in a large cohort of patients requiring long-term PN. Methods to reduce hospital and community nosocomial spread would likely be beneficial.
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Date
2021-05-06
Type
Article
Subject
Biochemistry, Paediatrics, Diet & nutrition, Endocrinology, Diabetes
Collections
Citation
Allan PJ, Ambrose T, Mountford C, Bond A, Donnellan C, Boyle R, Calvert C, Cernat E, Clarke E, Cooper SC, Donnelly S, Evans B, Glynn M, Hewett R, Holohan AS, Leitch EF, Louis-Auguste J, Mehta S, Naik S, Nightingale J, Rafferty G, Rodrigues A, Sharkey L, Small M, Teubner A, Urs A, Wyer N, Lal S. COVID-19 infection in patients with intestinal failure: UK experience. JPEN J Parenter Enteral Nutr. 2021 Aug;45(6):1369-1375. doi: 10.1002/jpen.2087. Epub 2021 May 6
Journal / Source Title
JPEN. Journal of Parenteral and Enteral Nutrition
DOI
10.1002/jpen.2087
PMID
33586170
Publisher
Wiley
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1941-2444