Expansive craniotomy versus standard decompressive craniectomy in refractory intracranial hypertension: a systematic review and meta-analysis
Saunders, Rachel Rees, Jemima Di Pietro, Valentina O'Halloran, Philip J Davies, David J Belli, Antonio Stevens, Andrew R
Saunders, Rachel
Rees, Jemima
Di Pietro, Valentina
O'Halloran, Philip J
Davies, David J
Belli, Antonio
Stevens, Andrew R
Abstract
Background: Raised intracranial pressure can have devastating consequences on mortality and outcome after acute brain injury. Decompressive craniectomy (DC) is an established surgical procedure for controlling refractory intracranial hypertension, though this requires subsequent cranioplasty. Expansive craniotomy (EC) techniques, where the bone flap is returned but only partially fixed in place, have been developed to avoid the need for cranioplasty. However, comparative safety and efficacy is not well-defined.
Methods: A systematic review to identify studies comparing EC to DC was performed in accordance with PRISMA guidelines, including all study types except systematic/scoping reviews. Meta-analysis was performed for three outcomes (mortality, acute reoperation rate, and Glasgow Outcome Scale (GOS)).
Results: 29 studies met the inclusion criteria, and are summarised in narrative review. Eight studies were included in meta-analysis: two randomised controlled trials (RCT) and six case-control studies. Meta-analysis found no significant difference in mortality. EC was associated with improved GOS (mean difference 0.44, p < 0.05), though this may be attributable to selection bias. There was a marginal increase in early additional surgery rates associated with EC (risk difference 0.08, p = 0.05). Risk of bias was moderate to high across included studies.
Conclusions: Current evidence cannot robustly inform clinical decision-making on the use of EC. Based upon reports of success of EC, EC appears to be a valid alternative to DC in selected cases, though greater acute reoperation rates owing to inadequate decompression is a risk. Overall there is strong support for an appropriately-powered RCT to robustly evaluate EC.
MIDER Authors
Date
2025-12-13
Type
Article
Subject
Craniectomy, Cerebral haemorrhage, Hypertension, Brain injuries, traumatic, Brain injuries, traumatic
Collections
Citation
Saunders R, Rees J, Di Pietro V, O'Halloran PJ, Davies DJ, Belli A, Stevens AR. Expansive craniotomy versus standard decompressive craniectomy in refractory intracranial hypertension: a systematic review and meta-analysis. World Neurosurg. 2025 Dec 13:124729. doi: 10.1016/j.wneu.2025.124729. Epub ahead of print.
Journal / Source Title
World Neurosurgery
DOI
10.1016/j.wneu.2025.124729
PMID
41397663
Publisher
Elsevier
Publisher’s URL
http://www.sciencedirect.com/science/journal/18788750