PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia
Abstract
The transcriptional mediator LIM domain only 2 (LMO2) forms a large multi-protein complex together with TAL1/LYL1, HEB/E2A, LDB1 and GATA. This complex regulates transcription from the onset of hematopoietic development and during differentiation. Chromosomal rearrangements involving LMO2 and TAL1 are causative for T-cell lymphoblastic leukemia (TALL). We have identified Plant Homeodomain (PHD)-like Finger 6 (PHF6) as a new LMO2 interacting factor. Somatic mutations in PHF6 have been found to occur in several types of leukemia. We show that PHF6 interacts with LMO2 as a part of the TAL1, GATA2, LDB1 complex in T-ALL and binds to the DNA. These findings show that PHF6 associates with the TAL1/LMO2/LDB1/GATA2 complex and regulates genes that have a major role in blood development, such as SPI1 (PU.1).
Date
2025-07-10
Type
Journal Article
Subject
Haematology, Practice of medicine, Diseases & disorders of systemic, metabolic or environmental origin
Collections
Citation
Stanulović VS, Binhassan S, Jaber BA, Alazmi S, Saleman FMB, Potluri S, Pratt G, Ludwig C, Ward DG, Hoogenkamp M. PHF6 interacts with the LMO2 complex in T-cell acute lymphoblastic leukemia. Haematologica. 2026 Jan 1;111(1):108-121. doi: 10.3324/haematol.2024.287124. Epub 2025 Jul 10.
Journal / Source Title
Haematologica
DOI
10.3324/haematol.2024.287124
PMID
40637766
Publisher
Ferrata storti foundation
Publisher’s URL
https://haematologica.org/article/view/12167