Sinonasal giant cell tumour. Report of four cases and review of the literature
Cremasco, Alice Modesti, Claudia Lodovica Da Pozzo, Filippo Iftikhar, Haissan Baj, Alessandro Calabrese, Luca Piazza, Cesare Dragonetti, Alberto Giulio Mattavelli, Davide Accorona, Remo
Cremasco, Alice
Modesti, Claudia Lodovica
Da Pozzo, Filippo
Iftikhar, Haissan
Baj, Alessandro
Calabrese, Luca
Piazza, Cesare
Dragonetti, Alberto Giulio
Mattavelli, Davide
Accorona, Remo
Abstract
OBJECTIVE: Sinonasal giant cell tumour (SnGCT) is very rarely reported. The aim of the study is to present a series of SnGCT treated with an endoscopic or combined approach and to carry out a review of the literature on this topic.
METHODS: This case series encompassed the clinical data of all the SnGCT surgically treated with curative intent at two different referral centres, between 2001 and 2024. The information was extrapolated to report epidemiologic and clinical data, surgical approach and follow up. A comprehensive clinical review of the literature was also carried out.
RESULTS: Among 4 patients included, 3 were treated with a pure endoscopic resection and remained disease-free at the last follow up, while one was managed with a combined approach, who is alive with disease. From the review we found only 32 cases of SnGCT reported, mostly treated with an open approach. Local recurrence was documented in 12.5% of cases, while distant metastasis in 3%.
CONCLUSIONS: SnGTC is a benign but locally aggressive neoplasm that can present as a lytic lesion. The clinical behaviour of GCT is unpredictable, and it tends to recur locally and may even metastasise. In the nose and paranasal sinuses it is an exceedingly rare entity, but should be considered in the differential diagnosis with a large variety of histologies. Surgery is the treatment of choice for resectable lesions.
MIDER Authors
Affiliations
Date
2026-04
Type
Article
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Citation
Cremasco A, Modesti CL, Da Pozzo F, Iftikhar H, Baj A, Calabrese L, Piazza C, Dragonetti AG, Mattavelli D, Accorona R. Sinonasal giant cell tumour. Report of four cases and review of the literature. Acta Otorhinolaryngol Ital. 2026 Apr;46(2):86-93. doi: 10.14639/0392-100X-A1248.