Nutrition and frailty: opportunities for prevention and treatment.
Ni Lochlainn, Mary Cox, Natalie J Wilson, Thomas Hayhoe, Richard P G Ramsay, Sheena E Granic, Antoneta Isanejad, Masoud Roberts, Helen C Wilson, Daisy Welch, Carly
Ni Lochlainn, Mary
Cox, Natalie J
Wilson, Thomas
Hayhoe, Richard P G
Ramsay, Sheena E
Granic, Antoneta
Isanejad, Masoud
Roberts, Helen C
Wilson, Daisy
Welch, Carly
Abstract
Frailty is a syndrome of growing importance given the global ageing population. While frailty is a multifactorial process, poor nutritional status is considered a key contributor to its pathophysiology. As nutrition is a modifiable risk factor for frailty, strategies to prevent and treat frailty should consider dietary change. Observational evidence linking nutrition with frailty appears most robust for dietary quality: for example, dietary patterns such as the Mediterranean diet appear to be protective. In addition, research on specific foods, such as a higher consumption of fruit and vegetables and lower consumption of ultra-processed foods are consistent, with healthier profiles linked to lower frailty risk. Few dietary intervention studies have been conducted to date, although a growing number of trials that combine supplementation with exercise training suggest a multi-domain approach may be more effective. This review is based on an interdisciplinary workshop, held in November 2020, and synthesises current understanding of dietary influences on frailty, focusing on opportunities for prevention and treatment. Longer term prospective studies and well-designed trials are needed to determine the causal effects of nutrition on frailty risk and progression and how dietary change can be used to prevent and/or treat frailty in the future.
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Date
2021-07-09
Type
Article
Subject
Collections
Citation
Ni Lochlainn M, Cox NJ, Wilson T, Hayhoe RPG, Ramsay SE, Granic A, Isanejad M, Roberts HC, Wilson D, Welch C, Hurst C, Atkins JL, Mendonça N, Horner K, Tuttiett ER, Morgan Y, Heslop P, Williams EA, Steves CJ, Greig C, Draper J, Corish CA, Welch A, Witham MD, Sayer AA, Robinson S. Nutrition and Frailty: Opportunities for Prevention and Treatment. Nutrients. 2021 Jul 9;13(7):2349. doi: 10.3390/nu13072349
Journal / Source Title
Nutrients
DOI
10.3390/nu13072349
PMID
34371858
Publisher
MDPI Publishing
Publisher’s URL
http://www.mdpi.com/journal/nutrients