Recurrent hyponatremia associated with sertraline and lofepramine
Bouman, Walter P. Johnson, Hazel
Bouman, Walter P.
Johnson, Hazel
Abstract
Reports a case of recurrent hyponatremia in a 78-yr-old woman with depression. One week after the start of sertraline (50 mg/day) therapy, S was admitted to hospital for complaints of feeling depressed, weak, and lethargic. The setraline treatment was discontinued and fluids were restricted to 1 liter/day. After 1 wk, the hyponatremia had resolved and a regimen of lofepramine (70 mg/day) was started. Two weeks after starting the lofepramine, her serum sodium level fell, and the serum and urine osmolality rose. Lofepramine was discontinued and the 1 liter restriction was reinstated. Everything normalized within a week. Finally, the S was treated with ECT. She made a full recovery and was placed on clozapine. (PsycINFO Database Record (c) 2016 APA, all rights reserved)
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Date
1997
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Article
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Citation
Bouman, W. P., Johnson, H., Trescoli-Serrano, C. & Jones, R. G. (1997). Recurrent hyponatremia associated with sertraline and lofepramine. The American Journal of Psychiatry, 154 (4), pp.580a-580.