Noninvasive instrument-based tests for detecting and measuring vitreous inflammation in uveitis: a systematic review
Liu, Xiaoxuan Hui, Benjamin Tk Way, Christopher Beese, Sophie Adriano, Ada Keane, Pearse A Moore, David J Denniston, Alastair K
Liu, Xiaoxuan
Hui, Benjamin Tk
Way, Christopher
Beese, Sophie
Adriano, Ada
Keane, Pearse A
Moore, David J
Denniston, Alastair K
Abstract
Purpose: This systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.
Methods: Studies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.
Results: Twelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.
Conclusion: Retinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.
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Date
2020-10-06
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Liu X, Hui BT, Way C, Beese S, Adriano A, Keane PA, Moore DJ, Denniston AK. Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review. Ocul Immunol Inflamm. 2022 Jan 2;30(1):137-148. doi: 10.1080/09273948.2020.1799038. Epub 2020 Oct 6