Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis
Wilson, Deborah Walsh, David A
Wilson, Deborah
Walsh, David A
Abstract
Background: The 28-joint DAS with ESR (DAS28-ESR) is used as a measure of inflammatory disease activity in RA. However, pain and non-inflammatory mechanisms (e.g. central sensitisation) might confound the DAS28 by modulating the visual analogue scale for general health (VAS-GH) and tender joint count (TJC). Several transformations have rearranged the DAS28 formula in an attempt to measure non-inflammatory pain contributions in RA. We aimed to compare different DAS28 components and these derived measures to assess their utility in the analysis of non-inflammatory factors and to inform interpretation of the DAS28 as an index of RA inflammatory disease activity.
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2016-04-28
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Citation
Daniel F. McWilliams, Deborah Wilson, Nalinie Joharatnam, Patrick D. G. Kiely, Adam Young, David A. Walsh; 243 Interpretation of 28-Joint Disease Activity Score and its Components in the Assessment of Inflammatory and Non-Inflammatory Aspects of Rheumatoid Arthritis, Rheumatology, Volume 55, Issue suppl_1, 1 April 2016, Pages i160, https://doi.org/10.1093/rheumatology/kew184.004