Consensus on acromegaly therapeutic outcomes: an update
Abstract
The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of medical management guidelines in 2018, new pharmacological agents and new treatment approaches have been developed. Fifty-two experts in the management of acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and management. Current outcome goals were considered, with a focus on the effect of current and emerging somatostatin receptor ligands, the growth hormone receptor antagonist pegvisomant and the dopamine agonist cabergoline on biochemical control, clinical control, adenoma mass and surgical outcomes. Participants assessed factors that determine pharmacological choices, as well as the proposed use of each agent. Here, we present consensus recommendations highlighting how an evidence-based acromegaly management algorithm could be optimized in clinical practice.
Author
Melmed, Shlomo
di Filippo, Luigi
Fleseriu, Maria
Mercado, Moisés
Karavitaki, Niki
Gurnell, Mark
Salvatori, Roberto
Tsagarakis, Stylianos
Losa, Marco
Maffei, Pietro
Pereira, Alberto M
Geer, Eliza B
Katznelson, Laurence
van der Lely, Aart Jan
Bollerslev, Jens
Esposito, Daniela
Webb, Susan M
Zatelli, Maria Chiara
Valassi, Elena
Neggers, Sebastian
Chanson, Philippe
Ho, Ken K Y
Ioachimescu, Adriana G
Biller, Beverly M K
Samson, Susan L
Kaiser, Ursula B
Schilbach, Katharina
Luque, Raúl M
Casanueva, Felipe F
Shimon, Ilan
Boguszewski, Cesar L
Biermasz, Nienke
Colao, Annamaria
Pirchio, Rosa
Lamberts, Steven W J
Kadioglu, Pinar
Buchfelder, Michael
Frara, Stefano
Chiloiro, Sabrina
Petersenn, Stephan
Gadelha, Monica R
Puig-Domingo, Manel
Luger, Anton
Brue, Thierry
Beckers, Albert
Ferone, Diego
Clemmons, David R
Greenman, Yona
Marazuela, Mónica
Mortini, Pietro
Strasburger, Christian J
Giustina, Andrea
di Filippo, Luigi
Fleseriu, Maria
Mercado, Moisés
Karavitaki, Niki
Gurnell, Mark
Salvatori, Roberto
Tsagarakis, Stylianos
Losa, Marco
Maffei, Pietro
Pereira, Alberto M
Geer, Eliza B
Katznelson, Laurence
van der Lely, Aart Jan
Bollerslev, Jens
Esposito, Daniela
Webb, Susan M
Zatelli, Maria Chiara
Valassi, Elena
Neggers, Sebastian
Chanson, Philippe
Ho, Ken K Y
Ioachimescu, Adriana G
Biller, Beverly M K
Samson, Susan L
Kaiser, Ursula B
Schilbach, Katharina
Luque, Raúl M
Casanueva, Felipe F
Shimon, Ilan
Boguszewski, Cesar L
Biermasz, Nienke
Colao, Annamaria
Pirchio, Rosa
Lamberts, Steven W J
Kadioglu, Pinar
Buchfelder, Michael
Frara, Stefano
Chiloiro, Sabrina
Petersenn, Stephan
Gadelha, Monica R
Puig-Domingo, Manel
Luger, Anton
Brue, Thierry
Beckers, Albert
Ferone, Diego
Clemmons, David R
Greenman, Yona
Marazuela, Mónica
Mortini, Pietro
Strasburger, Christian J
Giustina, Andrea
Date
2025-08-13
Type
Review
Subject
Acromegaly, Growth disorders, Treatment outcome
Collections
Citation
Melmed S, di Filippo L, Fleseriu M, Mercado M, Karavitaki N, Gurnell M, Salvatori R, Tsagarakis S, Losa M, Maffei P, Pereira AM, Geer EB, Katznelson L, van der Lely AJ, Bollerslev J, Esposito D, Webb SM, Zatelli MC, Valassi E, Neggers S, Chanson P, Ho KKY, Ioachimescu AG, Biller BMK, Samson SL, Kaiser UB, Schilbach K, Luque RM, Casanueva FF, Shimon I, Boguszewski CL, Biermasz N, Colao A, Pirchio R, Lamberts SWJ, Kadioglu P, Buchfelder M, Frara S, Chiloiro S, Petersenn S, Gadelha MR, Puig-Domingo M, Luger A, Brue T, Beckers A, Ferone D, Clemmons DR, Greenman Y, Marazuela M, Mortini P, Strasburger CJ, Giustina A. Consensus on acromegaly therapeutic outcomes: an update. Nat Rev Endocrinol. 2025 Nov;21(11):718-737. doi: 10.1038/s41574-025-01148-2. Epub 2025 Aug 13.
Journal / Source Title
Nature reviews. Endocrinology
DOI
10.1038/s41574-025-01148-2
PMID
40804505
Publisher
Nature Pub. Group
Publisher’s URL
http://www.nature.com/nrendo