Effect of Sodium Bicarbonate on Systolic Blood Pressure in CKD: A Systematic Review and Meta-Analysis.
Louca, Panayiotis Hoorn, Ewout J Menni, Cristina Padmanabhan, Sandosh
Louca, Panayiotis
Hoorn, Ewout J
Menni, Cristina
Padmanabhan, Sandosh
Abstract
Individuals with CKD are at a higher risk of cardiovascular morbidity and mortality. Acidosis is positively correlated with CKD progression and elevated systolic BP. Sodium bicarbonate is an efficacious treatment of acidosis, although this may also increase systolic BP. In this systematic review and meta-analysis, we summarize the evidence evaluating systolic BP and antihypertensive medication change (which may indicate systolic BP change) in response to sodium bicarbonate therapy in individuals with CKD.
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Date
2023-03-09
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Citation
Clin J Am Soc Nephrol. 2023 Apr 1;18(4):435-445