Angiosarcoma: a 10-year retrospective study from a high-volume UK regional referral centre.
Abstract
Purpose: Angiosarcoma (AS) is a rare malignancy with considerable heterogeneity seen in its aetiology, anatomical location, and clinicopathological behaviour. Diagnosis is often delayed and prognosis poor. The purpose of this study was to perform a retrospective review of all cases of AS over 10 years at a high-volume regional UK referral centre.
Methods/patients: We reviewed all cases of AS discussed at the sarcoma multidisciplinary meetings of University Hospitals Birmingham NHS Foundation Trust from September 2013 to August 2023. Demographic and clinicopathologic features at diagnosis, approaches to treatment, and outcomes were compared between four AS subtypes.
Results: A total of 130 cases were identified. The median age at diagnosis was 71 years, with the majority being female (78%). The most common AS subtype was radiation-induced AS (RIAS) (n = 72; 55%), followed by primary cutaneous (n = 28; 22%), primary non-cutaneous (n = 25; 19%), and AS secondary to lymphoedema (n = 5; 4%). Metastases were present at diagnosis in 18% of patients. Treatment was with surgery in the majority of patients (71%). The median survival for the cohort was 30 months (95% CI 20-40), although this differed significantly by AS subtype (p < 0.001), ranging from 5 months in primary non-cutaneous AS to 76 months in RIAS.
Conclusion: RIAS is the most common AS subtype, with surgery the only potentially curative treatment modality. Overall prognosis varies significantly by subtype. An international consensus on classification of AS subtypes is required to allow meaningful comparisons across studies and/or a prospective multi-centre registry.
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Date
2024-07-01
Type
Article
Subject
Oncology. Pathology., Vascular diseases
Collections
Citation
Morrow AA, Hodson J, Figura C, Bains S, Warner RM, Almond LM. Angiosarcoma: a 10-year retrospective study from a high-volume UK regional referral centre. Clin Transl Oncol. 2025 Jan;27(1):363-370. doi: 10.1007/s12094-024-03584-4. Epub 2024 Jul 1.
Journal / Source Title
Clinical and Translational Oncology
DOI
10.1007/s12094-024-03584-4
PMID
38951437
Publisher
Springer Italia
Publisher’s URL
https://link.springer.com/journal/12094