Testing for t(3;8) in MYC/BCL6 re-arranged large B cell lymphoma identifies a high risk subgroup with inferior survival
Abstract
A reciprocal t(3;8) BCL6::MYC fusion is common in large B cell lymphoma (LBCL) with MYC and BCL6 disruption. These pseudo-double hit cases are not adverse, whereas t(3;8) negative MYC/BCL6 lymphoma has an inferior prognosis relative to other MYC-rearranged LBCL.
Author
Maybury, Bernard D
James, Lisa J
Phillips, Neil
Venkatadasari, Indrani
Qureshi, Iman
Riley, James
Talbot, Georgina
Moosai, Shivir
Giles, Hannah
Chadderton, Nicola
Dowds, James
Rakesh, Pallav
Crosland, Henry
Haslam, Aidan
Lane, Sarah
Vega Gonzalez, Monica
Davies, David
Cherian, George
Shenouda, Amir
Kaudlay, Praveen
Starczynski, Jane
Rudzki, Zbigniew
Chaganti, Sridhar
James, Lisa J
Phillips, Neil
Venkatadasari, Indrani
Qureshi, Iman
Riley, James
Talbot, Georgina
Moosai, Shivir
Giles, Hannah
Chadderton, Nicola
Dowds, James
Rakesh, Pallav
Crosland, Henry
Haslam, Aidan
Lane, Sarah
Vega Gonzalez, Monica
Davies, David
Cherian, George
Shenouda, Amir
Kaudlay, Praveen
Starczynski, Jane
Rudzki, Zbigniew
Chaganti, Sridhar
Citations
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Date
2024-07-04
Type
Article
Subject
Oncology. Pathology.
Citation
Maybury BD, James LJ BSc (Hons), Phillips N, Venkatadasari I, Qureshi I, Riley JWE, Talbot G, Moosai S, Giles HV Dr, Chadderton N Mrs, Dowds J, Rakesh P, Crosland H, Haslam A, Lane S, Vega Gonzalez M, Davies D, Cherian G, Shenouda A, Kaudlay Sathyanarayana PK, Starczynski J, Rudzki Z, Chaganti S. Testing for t(3;8) in MYC/BCL6 re-arranged large B cell lymphoma identifies a high risk subgroup with inferior survival. Blood. 2024 Apr 22:blood.2024024048.
Journal / Source Title
Blood
DOI
10.1182/blood.2024024048
PMID
38648564
Publisher
American Society of Hematology