Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade
Morgan, Paul S
Morgan, Paul S
Abstract
Preoperative identification of high-grade gliomas is critical to optimize treatment strategy and to predict prognosis. To determine whether perilesional apparent diffusion coefficient (ADC) values differ between high- and low-grade tumors, we assessed water diffusivity within normal-appearing brain parenchyma (NABP) surrounding gliomas in twenty-one treatment-naive patients. This showed significantly lower mean and 25th percentile (Q1) ADC values in high- grade compared to low-grade gliomas respectively in the range of 10-25 and 10-30mm away from combined tumor and surrounding T2 signal. Thus, perilesional ADC measurement may reflect the extent of tumor infiltration beyond the abnormality seen on conventional MRI. Copyright © 2018 Elsevier Inc. All rights reserved.
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Date
2018
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Yazdani, M., Rumboldt, Z., Tabesh, A., Giglio, P., Schiarelli, C., Morgan, P.S. and Spampinato, M.V. (2018) 'Perilesional apparent diffusion coefficient in the preoperative evaluation of glioma grade', Clinical imaging, 52, pp. 88-94. doi: https://dx.doi.org/10.1016/j.clinimag.2018.07.005.