Sleep and liver disease: a bidirectional relationship.
Marjot, Thomas Ray, David W Williams, Felicity R Tomlinson, Jeremy W Armstrong, Matthew J
Marjot, Thomas
Ray, David W
Williams, Felicity R
Tomlinson, Jeremy W
Armstrong, Matthew J
Abstract
Sleep is a complex, highly regulated process essential for human health and wellbeing. Increasingly, sleep-wake disturbance has been implicated in the pathogenesis of chronic liver disease, particularly the development and progression of non-alcoholic fatty liver disease and alcohol-related liver disease. Patients with cirrhosis also have a high burden of sleep abnormalities with substantial implications for their quality of life and physical health. This Review summarises the epidemiology and pathophysiology of sleep-wake disturbance in liver disease and discusses the multiple converging pathways leading to abnormal sleeping patterns in patients with cirrhosis. This includes contributions from altered melatonin metabolism, neuromuscular complications, and aberrant thermoregulation. In turn, a vicious cycle is established whereby disrupted sleep can further contribute to liver disease progression. We also begin to unravel the complex, interlinking relationship between sleep-wake disturbance and hepatic encephalopathy, discussing both overlapping and distinct mechanisms and clinical features. Finally, we summarise the current and future therapeutic approaches aiming to improve sleep quality in patients with cirrhosis.
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Date
2021-07-15
Type
Article
Subject
Endocrinology, Diabetes
Collections
Citation
Marjot T, Ray DW, Williams FR, Tomlinson JW, Armstrong MJ. Sleep and liver disease: a bidirectional relationship. Lancet Gastroenterol Hepatol. 2021 Oct;6(10):850-863. doi: 10.1016/S2468-1253(21)00169-2. Epub 2021 Jul 15
Journal / Source Title
The Lancet Gastroenterology & Hepatology
DOI
10.1016/S2468-1253(21)00169-2
PMID
34273289
Publisher
Elsevier
Publisher’s URL
http://www.sciencedirect.com/science/journal/24681253