Loading...
Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation
Lam, Ching Marciani, Luca Costigan, Carolyn Hoad, Caroline L Spiller, Robin C
Lam, Ching
Marciani, Luca
Costigan, Carolyn
Hoad, Caroline L
Spiller, Robin C
Abstract
BACKGROUND: Functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C) share many symptoms but underlying mechanisms may be different. We have developed a magnetic resonance imaging (MRI) technique to measure intestinal volumes, transit, and motility in response to a laxative, Moviprep( R) . We aim to use these biomarkers to study the pathophysiology in IBS-C and FC., METHODS: Twenty-four FC and 24 IBS-C were studied. Transit was assessed using the weighted average position score (WAPS) of five MRI marker pills, taken 24 h before MRI scanning. Following baseline scan, participants ingested 1 L of Moviprep( R) followed by hourly scans. Magnetic resonance imaging parameters and bowel symptoms were scored from 0 to 4 h., KEY RESULTS: Weighted average position score for FC was 3.6 (2.5-4.2), significantly greater than IBS-C at 2.0 (1.5-3.2), p = 0.01, indicating slower transit for FC. Functional constipation showed greater fasting small bowel water content, 83 (63-142) mL vs 39 (15-70) mL in IBS-C, p 230 min distinguishes FC from IBS-C with low sensitivity of 55% but high specificity of 95%., CONCLUSION & INFERENCES: Our objective MRI biomarkers allow a distinction between FC and IBS-C. Copyright © 2016 The Authors. Neurogastroenterology & Motility published by John Wiley & Sons Ltd.
MIDER Authors
Affiliations
Citations
Altmetric:
Date
2016
Type
Article
Collections
Citation
Lam, C., Chaddock, G., Marciani, L., Costigan, C., Paul, J., Cox, E., Hoad, C., Menys, A., Pritchard, S., Garsed, K., Taylor, S., Atkinson, D., Gowland, P. and Spiller, R. (2016) 'Colonic response to laxative ingestion as assessed by MRI differs in constipated irritable bowel syndrome compared to functional constipation', Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 28(6), pp. 861-70. doi: https://dx.doi.org/10.1111/nmo.12784.