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Therapeutic management of idiosyncratic drug-induced liver injury and acetaminophen hepatotoxicity in the paediatric population: A systematic review

Atallah, Edmond
; 
Aithal, Guruprasad P.
Abstract
INTRODUCTION: Drug-induced liver injury (DILI) is a rare but serious adverse event that can progress to acute liver failure (ALF). The evidence for treatment of DILI in children is scarce. OBJECTIVE: We aimed to comprehensively review the available literature on the therapies for both acetaminophen overdose (APAP) and idiosyncratic DILI in the paediatric population. METHODS: We included original articles conducted in a paediatric population ( Copyright © 2022. The Author(s).
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Date
2022
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Article
Subject
Systematic review
 Chemical and drug induced liver injury
 Acute liver failure
 Paediatrics
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NUH Research and Innovation
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Niu, H., Atallah, E., Alvarez-Alvarez, I., Medina-Caliz, I., Aithal, G.P., Arikan, C., Andrade, R.J. and Lucena, M.I. (2022) 'Therapeutic management of idiosyncratic drug-induced liver injury and acetaminophen hepatotoxicity in the paediatric population: A systematic review', Drug Safety, 45(11), pp. 1329-1348. doi: 10.1007/s40264-022-01224-w https://doi.org/10.1007/s40264-022-01224-w.
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https://mider.dspace7.openrepository.com/handle/20.500.12904/18356
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