Population-level frequency of fluoroquinolone resistance by whole-genome sequencing drug predictions in Mycobacterium tuberculosis complex isolates in England from 2017-2023
Abstract
Fluoroquinolones are an important component of anti-tuberculosis treatment and identifying fluoroquinolone resistance is essential. We present the first survey of fluoroquinolone resistance in England from sequencing of over 16,000 unselected isolates. Fluoroquinolone resistance was 1.4% overall and 23.9% in multidrug-resistant TB. Routine sequencing allows resistance surveillance and should be widely adopted.
Citations
Altmetric:
Date
2024-11-13
Type
Article
Subject
Microbiology. Immunology, Communicable diseases, Public health. Health statistics. Occupational health. Health education, Pharmacology, Respiratory medicine
Collections
Citation
Ferran E, Chan C, Sheikh N, Dedicoat M, Alexander E, Gibertoni-Cruz A, Brown J, Robinson E, Lipman M. Population-level frequency of fluoroquinolone resistance by whole-genome sequencing drug predictions in Mycobacterium tuberculosis complex isolates in England from 2017-2023. Clin Infect Dis. 2024 Nov 13:ciae560. doi: 10.1093/cid/ciae560. Epub ahead of print.
Journal / Source Title
Clinical Infectious Diseases : an official publication of the Infectious Diseases Society of America
DOI
10.1093/cid/ciae560
PMID
39535753
Publisher
Oxford University Press
Publisher’s URL
https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciae560/7899844?login=false