Long term clinical remission on biologics: an analysis of real-world data from the UK severe asthma registry.
Redmond, Charlene Busby, John Mansur, Adel H Patel, Mitesh Patel, Pujan H Pfeffer, Paul E Heaney, Liam G Rupani, Hitasha
Redmond, Charlene
Busby, John
Mansur, Adel H
Patel, Mitesh
Patel, Pujan H
Pfeffer, Paul E
Heaney, Liam G
Rupani, Hitasha
Abstract
BACKGROUND: Clinical remission on biologics is an achievable goal for patients with severe asthma (SA). Most reports present short term follow-up, include small cohort sizes or present data on patients included in clinical trials.
OBJECTIVE: This study evaluates clinical remission rates in a real-world cohort of patients over the course of up to 4 years on different biologics and include those who switched biologic during this period. We also assess barriers and predictors of remission.
METHODS: Retrospective study of 525 patients in the UK SA registry who were initiated on a biologic between January 2015 and May 2022. Clinical remission was assessed at two time points: first review (9-24 months) and long-term review (30-48 months), and defined as controlled asthma (ACQ6<1.5), no exacerbations in the preceding 12 months and no maintenance oral corticosteroid use.
RESULTS: Clinical remission was achieved in 25.1% at first review, increasing to 32.1% at long-term reivew. This improvement occurred regardless of biologic switching. Among those in remission at first review, 69.7% remained in remission at long-term review while 45.6% of those in long-term remission had not been in remission at first review. Higher symptoms burden and presence of anxiety/depression was negatively associated with achieving long-term remission. Advanced age at baseline and the presence of nasal polyps increased likelihood of long-term remission.
CONCLUSION: In this large real-world cohort of patients with SA, there is a progressive increase in remission rates over 4 years, which is influenced by the presence of comorbidities but is largely independent of biologic switching.
MIDER Authors
Mansur, Adel H
Citations
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Date
2025-10-22
Type
Article
Subject
Asthma, Biological products
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Citation
Redmond C, Busby J, Mansur AH, Patel M, Patel PH, Pfeffer PE, Heaney LG, Rupani H; UKSAR. Long-Term Clinical Remission on Biologics: An Analysis of Real-World Data From the UK Severe Asthma Registry. J Allergy Clin Immunol Pract. 2026 Feb;14(2):436-444.e5. doi: 10.1016/j.jaip.2025.10.011. Epub 2025 Oct 22.
Journal / Source Title
The Journal of Allergy and Clinical Immunology. In Practice
DOI
10.1016/j.jaip.2025.10.011
PMID
41135851
Publisher
Elsevier Inc.
Publisher’s URL
http://www.sciencedirect.com/science/journal/22132198