Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression
Patel, Kishen Rajan Lee, Lennard Yw Tripathy, Arvind McKean, David
Patel, Kishen Rajan
Lee, Lennard Yw
Tripathy, Arvind
McKean, David
Abstract
A 56-year-old man undergoing immunotherapy treatment for metastatic melanoma presented with sudden onset testicular pain radiating into his abdomen. On examination, the abdomen was generally tender with associated guarding. Imaging revealed a perforation of the small bowel at the site of a metastatic lesion. Histology revealed that this process was non-inflammatory in nature. A diagnosis of small bowel perforation secondary to immunotherapy driven rapid tumour regression was made. The patient was treated with a small bowel resection plus anastomosis and made a full recovery. This case highlights the rare potential side effect of immunotherapy in causing non-inflammatory bowel perforations secondary to rapid tumour regression.
MIDER Authors
Affiliations
University Hospitals Birmingham NHS Foundation Trust; Buckinghamshire Healthcare NHS Trust
Date
2020-02-20
Type
Article
Collections
Citation
Patel KR, Lee LY, Tripathy A, McKean D. Case of small bowel perforation secondary to nivolumab and ipilimumab related tumour regression. BMJ Case Rep. 2020 Feb 20;13(2):e232304. doi: 10.1136/bcr-2019-232304.