Distribution, severity, and management of joint pain in patients with acromegaly
Kyriakakis, Nikolaos Heague, Megan Hebden, Sophie Safdar, Nawaz McLaren, David S Tresoldi, Alberto S Lithgow, Kirstie Urwyler, Sandrine Varsani, Chetna Akbar, Shahzad
Kyriakakis, Nikolaos
Heague, Megan
Hebden, Sophie
Safdar, Nawaz
McLaren, David S
Tresoldi, Alberto S
Lithgow, Kirstie
Urwyler, Sandrine
Varsani, Chetna
Akbar, Shahzad
Abstract
OBJECTIVE: The acromegaly-associated arthropathy (AcAA) is a determinant of long-term impaired quality of life. There are limited data assessing the impact of arthropathy, determinants of future arthropathy, and current management.
DESIGN: Multicentre cross-sectional questionnaire study of arthropathy in 6 UK endocrine centres.
METHODS: The study incorporated questionnaires relating to distribution of arthralgia, severity of pain, and clinical management of AcAA. Demographics and laboratory data were extracted from medical records.
RESULTS: We enrolled 411 patients (210 female, median 60, IQR 50-69 years) and median 13 (IQR 6-22) years since diagnosis. Joint pain was reported by 82.5%, with 43.3% and 13.1% experiencing moderate and severe joint pain respectively. The most frequently affected joints were knees (54.7%), lower back (47.7%), hips (38.9%), and shoulders (38.6%). Two hundred and forty-seven (60.1%) were taking at least one analgesic, 137 (33.3%) at least 2 classes of analgesics. One hundred and nine (26.5%) patients had at least one joint injection (median 2, 1-20). Seventy (17.0%) had at least one joint prosthesis (median 2, 1-6), at median age 59 (32-82) years. A similar percentage (17.0%) had other forms of joint surgery. Patients aged ≤50 years experienced less pain, required fewer joint injections and less joint surgery, but a similar prevalence of analgesic use, with 36.4% and 10.3% reporting moderate or severe pain.
CONCLUSION: This study therefore highlights the burden of arthropathy in patients with acromegaly, estimates the need for therapeutic interventions, and the impact on health services.
MIDER Authors
Date
2026-03-04
Type
Article
Subject
Acromegaly, Analgesia, Arthropathy, neurogenic, Pain management
Collections
Citation
Kyriakakis N, Heague M, Hebden S, Safdar N, McLaren DS, Tresoldi AS, Lithgow K, Urwyler S, Varsani C, Akbar S, McLoughlin K, Adeniji K, Kearney T, Drake WM, Sathyapalan T, Higham CE, Karavitaki N, Lynch J, Murray RD. Distribution, severity, and management of joint pain in patients with acromegaly. Eur J Endocrinol. 2026 Mar 4;194(3):413-421. doi: 10.1093/ejendo/lvag045.
Journal / Source Title
European Journal of Endocrinology
DOI
10.1093/ejendo/lvag045
PMID
41783995
Publisher
Oxford University Press
Publisher’s URL
https://academic.oup.com/ejendo/