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Noncontrast computed tomography signs as predictors of hematoma expansion, clinical outcome, and response to tranexamic acid in acute intracerebral hemorrhage
Krishnan, Kailash Appleton, Jason P. Dineen, Robert A. Bath, Philip M. Sprigg, Nikola
Krishnan, Kailash
Appleton, Jason P.
Dineen, Robert A.
Bath, Philip M.
Sprigg, Nikola
Abstract
Background and Purpose - Blend, black hole, island signs, and hypodensities are reported to predict hematoma expansion in acute intracerebral hemorrhage. We explored the value of these noncontrast computed tomography signs in predicting hematoma expansion and functional outcome in our cohort of intracerebral hemorrhage. Methods - The TICH-2 (Tranexamic acid for IntraCerebral Hemorrhage-2) was a prospective randomized controlled trial exploring the efficacy and safety of tranexamic acid in acute intracerebral hemorrhage. Baseline and 24-hour computed tomography scans of trial participants were analyzed. Hematoma expansion was defined as an increase in hematoma volume of >33% or >6 mL on 24-hour computed tomography. Poor functional outcome was defined as modified Rankin Scale of 4 to 6 at day 90. Multivariable logistic regression was performed to identify predictors of hematoma expansion and poor functional outcome. Results - Of 2325 patients recruited, 2077 (89.3%) had valid baseline and 24-hour scans. Five hundred seventy patients (27.4%) had hematoma expansion while 1259 patients (54.6%) had poor functional outcome. The prevalence of noncontrast computed tomography signs was blend sign, 366 (16.1%); black hole sign, 414 (18.2%); island sign, 200 (8.8%); and hypodensities, 701 (30.2%). Blend sign (adjusted odds ratio aOR] 1.53 95% CI, 1.16-2.03]; P=0.003), black hole (aOR, 2.03 1.34-3.08]; P=0.001), and hypodensities (aOR, 2.06 1.48-2.89]; P0.05). Conclusions - Blend sign, black hole sign, and hypodensities predict hematoma expansion while black hole sign, hypodensities, and island signs predict poor functional outcome. Noncontrast computed tomography signs did not predict a better response to tranexamic acid.Copyright © 2019 The Authors.
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Date
2020
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Law, Z.K., Ali, A., Krishnan, K., Bischoff, A., Appleton, J.P., Scutt, P., Woodhouse, L., Pszczolkowski, S., Cala, L.A., Dineen, R.A., England, T.J., Ozturk, S., Roffe, C., Bereczki, D., Ciccone, A., Christensen, H., Ovesen, C., Bath, P.M., Sprigg, N. and TICH-2 Investigators (2020) 'Noncontrast computed tomography signs as predictors of hematoma expansion, clinical outcome, and response to tranexamic acid in acute intracerebral hemorrhage', Stroke, 51(1), pp. 121–128. doi: 10.1161/STROKEAHA.119.026128 https://doi.org/10.1161/strokeaha.119.026128.