Skull base surgery in the pediatric population-the 2nd International Collaborative Study (1995-2015)
Fliss, Dan M Ungar, Omer J Levyn, Helena Valero, Cristina Adilbay, Dauren Eagan, Alana Zheng, Junting Gonen, Mithat Cohen, Marc A Patel, Snehal
Fliss, Dan M
Ungar, Omer J
Levyn, Helena
Valero, Cristina
Adilbay, Dauren
Eagan, Alana
Zheng, Junting
Gonen, Mithat
Cohen, Marc A
Patel, Snehal
Abstract
Background: The current study presents the efforts of a global collaborative group to review the management and outcomes of malignant tumors of the skull base in the pediatric population worldwide.
Patients and methods: A total of 28 institutions contributed data on 3061 patients. From this, there were 64 pediatric patients (2.1%). Clinical variables, overall and disease-free survival (OS and DFS) outcomes, and multivariable factors associated with outcome were evaluated.
Results: The male-to-female ratio was 37:27 and the median [IQR] age at diagnosis was 14.0 [9.6-16.0] years. The most common malignancy was sarcoma (57.8%), followed by esthesioneuroblastoma (25.0%) and carcinoma (17.2%). Negative margins were achieved in 53.1% children. Dural invasion was associated with reduced OS and DFS. Adjuvant radiotherapy was associated with improved survival outcomes.
Conclusions: Open approaches were widely used for pediatric skull base tumor resection in the period between 1995 and 2015 but we saw a rise in the use of endoscopic and combined techniques by the end of the period covered by this study. Our results may represent a transitional era in which alternative endoscopic techniques continue to expand.
MIDER Authors
Date
2026-02-11
Type
Article
Subject
Endoscopy, Skull base, Paediatrics, Head and neck neoplasms, Endoscopy
Collections
Citation
Fliss DM, Ungar OJ, Levyn H, Valero C, Adilbay D, Eagan A, Zheng J, Gonen M, Cohen MA, Patel S, Ganly I, Pai P, Castelnuovo P, Gao FJ, Piazza C, Nicolai P, Panizza BJ, Bowman J, Barnett C, Kowalski LP, Toledo RN, DeAlmeida J, Witterick I, Herman P, Fontanella W, Aniceto GS, Hosal S, Ozer S, Iyer S, Harvey R, Leemans CR, Hendrickx JJ, Figari M, Boccalatte L, Nibu I, Clarke P, Rennie C, Zhu Y, Cernea C, Goncalves S, Schlosser R, Dias F, Sargi Z, Ahmed S, Golusinski W, Kim SH, Su SY, Raza SM, DeMonte F, Hanna E, Shah JP. Skull Base Surgery in the Pediatric Population-The 2nd International Collaborative Study (1995-2015). Head Neck. 2026 Feb 11. doi: 10.1002/hed.70168. Epub ahead of print.
Journal / Source Title
Head & Neck
DOI
10.1002/hed.70168
PMID
41670175
Publisher
John Wiley And Sons
Publisher’s URL
https://onlinelibrary.wiley.com/journal/10970347