Assessment of efficacy of various anesthetic agents in reduction of nausea and vomiting postoperatively : a comparative study
Nayak, Amiya K Kurian, Sujith A Bhandary, Avanish Misra, K K Nalakath, Hafis Syamkumarz, V Attar, Juberahamad R Paulose, Leena
Nayak, Amiya K
Kurian, Sujith A
Bhandary, Avanish
Misra, K K
Nalakath, Hafis
Syamkumarz, V
Attar, Juberahamad R
Paulose, Leena
Abstract
Background: "Postoperative nausea and vomiting (PONV)" are frequent adverse effects following anesthesia, which may exert significant implications on patient postoperative recovery and comfort. Current trial aimed to compare the efficacy of Remimazolam in relation to Propofol for reducing PONV in surgical patients. Methods: A randomized controlled trial was conducted with patients scheduled for elective surgery under general anesthesia. A group of patients was given Remimazolam, and another propofol. The incidence of PONV and severity of nausea were determined, the number of episodes of vomiting were recorded, and the requirement for rescue antiemetics was also noted at 24 hours post-surgery. Results: Overall PONV incidence was significantly lower in Remimazolam group (12%) as compared to Propofol group (34%), P = 0.02. Rescue antiemetics were also less used in the Remimazolam group (8%) than in the Propofol group (27%) (P = 0.03). The Remimazolam group also showed a lower VAS score by nausea severity (P = 0.04). Conclusion: Compared with Propofol, Remimazolam had the best effectiveness in PONV events, necessity of using rescue antiemetics and degree of nausea at point. These findings may indicate that Remimazolam is a more suitable anesthetic for high-risk PONV patients.
MIDER Authors
Date
2025-06-20
Type
Article
Subject
Anaesthetics, Postoperative Nausea and Vomiting, Surgery
Collections
Citation
Nayak AK, Kurian SA, Bhandary A, Misra KK, Nalakath H, Syamkumarz V, Attar JR, Paulose L. Assessment of Efficacy of Various Anesthetic Agents in Reduction of Nausea and Vomiting Postoperatively: A Comparative Study. J Pharm Bioallied Sci. 2025 Sep;17(Suppl 3):S2482-S2484. doi: 10.4103/jpbs.jpbs_1858_24. Epub 2025 Jun 2
Journal / Source Title
Journal of Pharmacy & Bioallied Science
DOI
10.4103/jpbs.jpbs_1858_24
PMID
Publisher
Medknow Publications