Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis.
Abstract
The search led to 13 studies of low-moderate risk of bias including 2,164 patients. Early mobilisation reduced the risk of delirium by 47 % (13 studies, 2,164 patients, low to moderate risk of bias: Odds Ratio 0.53 (95 % Confidence Interval 0.34 till 0.83, p = 0.01), with significant heterogeneity (I2 = 78 %, p < 0.001). Early mobilisation also reduced the duration of delirium by 1.8 days (3 studies, 296 patients, low-moderate risk of bias: Mean difference -1.78 days (95 % Confidence Interval -2.73 till -0.83 days, p < 0.001), heterogeneity 0 % (p = 0.41). Other analyses such as low risk of bias studies, randomised trials, studies published ≥ 2017, high intensity, and mobilisation as stand-alone intervention showed no significant results, with conflicting certainty of evidence and high heterogeneity. meta-regression could not explain heterogeneity.
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Date
2022-10-27
Type
Article
Subject
Intensive care, Physiotherapy
Citation
Nydahl P, Jeitziner MM, Vater V, Sivarajah S, Howroyd F, McWilliams D, Osterbrink J. Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis. Intensive Crit Care Nurs. 2023 Feb;74:103334. doi: 10.1016/j.iccn.2022.103334. Epub 2022 Oct 27.
Journal / Source Title
Intensive and Critical Care Nursing
DOI
10.1016/j.iccn.2022.103334
PMID
37440187
Publisher
Elsevier