Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis.
Nydahl, Peter Jeitziner, Marie-Madlen Vater, Vanessa Sivarajah, Sayantha Howroyd, Fiona Osterbrink, Jürgen
Nydahl, Peter
Jeitziner, Marie-Madlen
Vater, Vanessa
Sivarajah, Sayantha
Howroyd, Fiona
Osterbrink, Jürgen
Abstract
The search led to 13 studies of low-moderate risk of bias including 2,164 patients. Early mobilisation reduced the risk of delirium by 47 % (13 studies, 2,164 patients, low to moderate risk of bias: Odds Ratio 0.53 (95 % Confidence Interval 0.34 till 0.83, p = 0.01), with significant heterogeneity (I2 = 78 %, p < 0.001). Early mobilisation also reduced the duration of delirium by 1.8 days (3 studies, 296 patients, low-moderate risk of bias: Mean difference -1.78 days (95 % Confidence Interval -2.73 till -0.83 days, p < 0.001), heterogeneity 0 % (p = 0.41). Other analyses such as low risk of bias studies, randomised trials, studies published ≥ 2017, high intensity, and mobilisation as stand-alone intervention showed no significant results, with conflicting certainty of evidence and high heterogeneity. meta-regression could not explain heterogeneity.
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Date
2022-10-27
Type
Article
Subject
Citation
Nydahl P, Jeitziner MM, Vater V, Sivarajah S, Howroyd F, McWilliams D, Osterbrink J. Early mobilisation for prevention and treatment of delirium in critically ill patients: Systematic review and meta-analysis. Intensive Crit Care Nurs. 2023 Feb;74:103334. doi: 10.1016/j.iccn.2022.103334. Epub 2022 Oct 27.
Journal / Source Title
Intensive and Critical Care Nursing
DOI
10.1016/j.iccn.2022.103334
PMID
37440187
Publisher
Elsevier