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Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium.

Abstract
Considerable heterogeneity exists in the literature concerning genetic determinants of the age at onset (AAO) of Parkinson disease (PD), which could be attributed to a lack of well-powered replication cohorts. The previous largest genome-wide association studies (GWAS) identified SNCA and TMEM175 loci on chromosome (Chr) 4 with a significant influence on the AAO of PD; these have not been independently replicated. This study aims to conduct a meta-analysis of GWAS of PD AAO and validate previously observed findings in worldwide populations.
Author
Grover, Sandeep
Kumar Sreelatha, Ashwin Ashok
Pihlstrom, Lasse
Domenighetti, Cloé
Schulte, Claudia
Sugier, Pierre-Emmanuel
Radivojkov-Blagojevic, Milena
Lichtner, Peter
Mohamed, Océane
Portugal, Berta
Landoulsi, Zied
May, Patrick
Bobbili, Dheeraj
Edsall, Connor
Bartusch, Felix
Hanussek, Maximilian
Krüger, Jens
Hernandez, Dena G
Blauwendraat, Cornelis
Mellick, George D
Zimprich, Alexander
Pirker, Walter
Tan, Manuela
Rogaeva, Ekaterina
Lang, Anthony
Koks, Sulev
Taba, Pille
Lesage, Suzanne
Brice, Alexis
Corvol, Jean-Christophe
Chartier-Harlin, Marie-Christine
Mutez, Eugenie
Brockmann, Kathrin
Deutschländer, Angela B
Hadjigeorgiou, Georges M
Dardiotis, Efthimos
Stefanis, Leonidas
Simitsi, Athina Maria
Valente, Enza Maria
Petrucci, Simona
Straniero, Letizia
Zecchinelli, Anna
Pezzoli, Gianni
Brighina, Laura
Ferrarese, Carlo
Annesi, Grazia
Quattrone, Andrea
Gagliardi, Monica
Burbulla, Lena F
Matsuo, Hirotaka
Kawamura, Yusuke
Hattori, Nobutaka
Nishioka, Kenya
Chung, Sun Ju
Kim, Yun Joong
Pavelka, Lukas
van de Warrenburg, Bart P C
Bloem, Bastiaan R
Singleton, Andrew B
Aasly, Jan
Toft, Mathias
Guedes, Leonor Correia
Ferreira, Joaquim J
Bardien, Soraya
Carr, Jonathan
Tolosa, Eduardo
Ezquerra, Mario
Pastor, Pau
Diez-Fairen, Monica
Wirdefeldt, Karin
Pedersen, Nancy L
Ran, Caroline
Belin, Andrea C
Puschmann, Andreas
Hellberg, Clara
Clarke, Carl E
Morrison, Karen E
Krainc, Dimitri
Farrer, Matt J
Kruger, Rejko
Elbaz, Alexis
Gasser, Thomas
Sharma, Manu
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Date
2022-05-26
Type
Article
Subject
Neurology
Collections
Research (Articles)
GEH Oral Surgery
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Citation
Grover S, Kumar Sreelatha AA, Pihlstrom L, Domenighetti C, Schulte C, Sugier PE, Radivojkov-Blagojevic M, Lichtner P, Mohamed O, Portugal B, Landoulsi Z, May P, Bobbili D, Edsall C, Bartusch F, Hanussek M, Krüger J, Hernandez DG, Blauwendraat C, Mellick GD, Zimprich A, Pirker W, Tan M, Rogaeva E, Lang A, Koks S, Taba P, Lesage S, Brice A, Corvol JC, Chartier-Harlin MC, Mutez E, Brockmann K, Deutschländer AB, Hadjigeorgiou GM, Dardiotis E, Stefanis L, Simitsi AM, Valente EM, Petrucci S, Straniero L, Zecchinelli A, Pezzoli G, Brighina L, Ferrarese C, Annesi G, Quattrone A, Gagliardi M, Burbulla LF, Matsuo H, Kawamura Y, Hattori N, Nishioka K, Chung SJ, Kim YJ, Pavelka L, van de Warrenburg BPC, Bloem BR, Singleton AB, Aasly J, Toft M, Guedes LC, Ferreira JJ, Bardien S, Carr J, Tolosa E, Ezquerra M, Pastor P, Diez-Fairen M, Wirdefeldt K, Pedersen NL, Ran C, Belin AC, Puschmann A, Hellberg C, Clarke CE, Morrison KE, Krainc D, Farrer MJ, Kruger R, Elbaz A, Gasser T, Sharma M; and the Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (COURAGE-PD) Consortium. Genome-wide Association and Meta-analysis of Age at Onset in Parkinson Disease: Evidence From the COURAGE-PD Consortium. Neurology. 2022 Aug 16;99(7):e698-e710. doi: 10.1212/WNL.0000000000200699. Epub 2022 May 26. PMID: 35970579; PMCID: PMC9484604.
Journal / Source Title
Neurology
DOI
10.1212/WNL.0000000000200699
URI
http://hdl.handle.net/20.500.14200/1991
PMID
35970579
Publisher
Lippincott, Williams & Wilkins
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Note / Copyright