British Rhinological Society Consensus Guidance on the use of biological therapies for chronic rhinosinusitis with nasal polyps.
Hopkins, Claire McKenzie, Jo-Lyn Anari, Shahram Carrie, Sean Ramakrishnan, Yujay Kara, Naveed Philpott, Carl Hobson, Jonathan Qureishi, Ali Stew, Ben
Hopkins, Claire
McKenzie, Jo-Lyn
Anari, Shahram
Carrie, Sean
Ramakrishnan, Yujay
Kara, Naveed
Philpott, Carl
Hobson, Jonathan
Qureishi, Ali
Stew, Ben
Abstract
Objectives: We set out to create Consensus Guidelines, based on current evidence and relative risks of adverse effects and the costs of different treatments, which reflect the views of the British Rhinological Society (BRS) Council on where the use of biologics should be positioned within treatment pathways for CRSwNP, specifically in the setting of the National Health Service (NHS).
Design: An expert panel of 16 members was assembled. A review of the literature and evidence synthesis was undertaken and circulated to the panel. We used the RAND/UCLA methodology with a multi-step process to make recommendations on the use of biologics.
Setting: N/A.
Participants: N/A.
Results: Recommendations were made, based on underlying disease severity, prior treatments and co-morbidities. A group of patients for whom biologics were considered an appropriate treatment option for CRSwNP was defined.
Conclusions: Although biologics are not currently available for the treatment of CRSwNP, the BRS Council have defined a group of patients who have higher rates of "failure" with current treatment pathways, higher resource use and are more likely to suffer with uncontrolled symptoms. We would urge NICE to consider approval of biologics for such indications without applying further restrictions on use.
MIDER Authors
Citations
Altmetric:
Date
2021-04-05
Type
Article
Subject
Ear, Nose & Throat
Collections
Citation
Hopkins C, McKenzie JL, Anari S, Carrie S, Ramakrishnan Y, Kara N, Philpott C, Hobson J, Qureishi A, Stew B, Bhalla R, Gane S, Walker A, Harries P, Hathorn I, Lund V. British Rhinological Society Consensus Guidance on the use of biological therapies for chronic rhinosinusitis with nasal polyps. Clin Otolaryngol. 2021 Sep;46(5):1037-1043. doi: 10.1111/coa.13779. Epub 2021 Apr 22.
Journal / Source Title
Clinical Otolaryngology
DOI
10.1111/coa.13779
PMID
33817954
Publisher
Blackwell Scientific Publications
Publisher’s URL
https://pubmed.ncbi.nlm.nih.gov/33817954/