Biomarkers of liver injury during transplantation in an era of machine perfusion
Bhogal, Ricky H Mirza, Darius F Afford, Simon C Mergental, Hynek
Bhogal, Ricky H
Mirza, Darius F
Afford, Simon C
Mergental, Hynek
Abstract
Liver ischaemia-reperfusion injury (IRI) is an intrinsic part of the transplantation process and damages the parenchymal cells of the liver including hepatocytes, endothelial cells and cholangiocytes. Many biomarkers of IRI have been described over the past two decades that have attempted to quantify the extent of IRI involving different hepatic cellular compartments, with the aim to allow clinicians to predict the suitability of donor livers for transplantation. The advent of machine perfusion has added an additional layer of complexity to this field and has forced researchers to re-evaluate the utility of IRI biomarkers in different machine preservation techniques. In this review, we summarise the current understanding of liver IRI biomarkers and discuss them in the context of machine perfusion.
MIDER Authors
Affiliations
University of Birmingham; University Hospitals Birmingham NHS Foundation Trust; The Royal Marsden Hospital NHS Foundation Trust
Citations
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Date
2020-02-25
Type
Article
Subject
Collections
Citation
Bhogal RH, Mirza DF, Afford SC, Mergental H. Biomarkers of Liver Injury during Transplantation in an Era of Machine Perfusion. Int J Mol Sci. 2020 Feb 25;21(5):1578. doi: 10.3390/ijms21051578.