Cerebral venous system and anatomical predisposition to high-altitude headache.
Abstract
Objective: As inspired oxygen availability falls with ascent to altitude, some individuals develop high-altitude headache (HAH). We postulated that HAH results when hypoxia-associated increases in cerebral blood flow occur in the context of restricted venous drainage, and is worsened when cerebral compliance is reduced. We explored this hypothesis in 3 studies.
Author
Wilson, Mark H
Davagnanam, Indran
Holland, Graeme
Dattani, Raj S
Tamm, Alexander
Hirani, Shashivadan P
Kolfschoten, Nicky
Strycharczuk, Lisa
Green, Cathy
Thornton, John S
Wright, Alex
Edsell, Mark
Kitchen, Neil D
Sharp, David J
Ham, Timothy E
Murray, Andrew
Holloway, Cameron J
Clarke, Kieran
Grocott, Mike P W
Montgomery, Hugh
imray, chris
Davagnanam, Indran
Holland, Graeme
Dattani, Raj S
Tamm, Alexander
Hirani, Shashivadan P
Kolfschoten, Nicky
Strycharczuk, Lisa
Green, Cathy
Thornton, John S
Wright, Alex
Edsell, Mark
Kitchen, Neil D
Sharp, David J
Ham, Timothy E
Murray, Andrew
Holloway, Cameron J
Clarke, Kieran
Grocott, Mike P W
Montgomery, Hugh
imray, chris
Citations
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Date
2013-02-26
Type
Article
Subject
Diseases & disorders of systemic, metabolic or environmental origin
Collections
Citation
Wilson MH, Davagnanam I, Holland G, Dattani RS, Tamm A, Hirani SP, Kolfschoten N, Strycharczuk L, Green C, Thornton JS, Wright A, Edsell M, Kitchen ND, Sharp DJ, Ham TE, Murray A, Holloway CJ, Clarke K, Grocott MP, Montgomery H, Imray C; Birmingham Medical Research Expeditionary Society and Caudwell Xtreme Everest Research Group. Cerebral venous system and anatomical predisposition to high-altitude headache. Ann Neurol. 2013 Mar;73(3):381-9. doi: 10.1002/ana.23796. Epub 2013 Feb 26.
Journal / Source Title
Annals of Neurology
DOI
10.1002/ana.23796
PMID
23444324
Publisher
Wiley