A case of VIPoma
Crawford, L Amin, V
Crawford, L
Amin, V
Abstract
This case report addresses the management of a pregnant woman in the peripartum period with a VIPoma. This rare and highly malignant neuroendocrine tumour secretes vasoactive intestinal peptide (VIP), a substance that may cause potentially life-threatening disruption to physiology. A 36-year-old woman presented for induction of labour with a three-year history of chronic diarrhoea, hypophosphataemia, palpitations and skin flushing. Raised VIP levels indicated presence of a VIPoma, however despite extensive investigation prior to pregnancy by neuroendocrine specialists, the tumour location remained unidentified. The patient delivered a healthy boy with the aid of forceps in theatre following an epidural top-up. Key features of management were a multidisciplinary approach, avoidance of triggers for VIP secretion, strict management of electrolytes and avoidance of severe changes in sympathetic tone during labour with epidural analgesia.
MIDER Authors
Affiliations
The Dudley Group NHS Foundation Trust
Date
2022-09-28
Type
Journal Article
Subject
Collections
Citation
Crawford L, Amin V. A case of VIPoma. Int J Obstet Anesth. 2022 Nov;52:103600. doi: 10.1016/j.ijoa.2022.103600