Publication

Autoimmune neuropathies: new guidelines and expert insights into clinical decision making

van Doorn, Pieter A
; 
Sommer, Claudia
; 
Rajabally, Yusuf A
Abstract
Introduction: Guillain-Barré syndrome (GBS) and chronic demyelinating polyneuropathy (CIDP) are immune-mediated demyelinating neuropathies that may have similar symptoms in their early stages. GBS is generally monophasic with acute, progressive, flaccid paralysis of the extremities accompanied by reduced/absent reflexes. The onset of GBS is often 1-2 weeks after a precipitating event and reaches its nadir by 4 weeks. With CIDP the progressive phase by definition lasts more than 2 months, although it can be shorter in acute-onset forms which initially resemble GBS. Areas covered: In this review, the diagnostic criteria and treatment options from recent European Academy of Neurology (EAN)/Peripheral Nerve Society (PNS) guidelines for GBS and CIDP and current literature will be discussed addressing basic and advanced diagnostics, differential diagnoses, antecedent events, risk factors and therapeutic options. Expert opinion/commentary: The guidelines can assist with evidence-based diagnosis and treatment of GBS and CIDP by providing critically evaluated, well-documented evidence to support clinical decisions. Individualized diagnostic and therapeutic approaches are warranted due to heterogenous patient populations and disease presentations.
MIDER Authors
Rajabally, Yusuf
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Date
2025-11-17
Type
Article
Subject
Practice guideline, Demyelinating diseases, Autoimmune diseases, Diagnosis, Practice guideline
Collections
UHB Neurology
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Citation
van Doorn PA, Sommer C, Rajabally YA. Autoimmune neuropathies: New guidelines and expert insights into clinical decision making. J Neurol Sci. 2025 Dec 15;479:125659. doi: 10.1016/j.jns.2025.125659. Epub 2025 Nov 17.
Journal / Source Title
Journal of the Neurological Sciences
DOI
10.1016/j.jns.2025.125659
URI
https://mider.dspace7.openrepository.com/handle/20.500.14200/9178
PMID
41308579
Publisher
Elsevier
Publisher’s URL
https://www.sciencedirect.com/journal/journal-of-the-neurological-sciences
Publisher’s statement
Note / Copyright