Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic
Abstract
Traumatic brain injury (TBI), a major cause of morbidity and mortality worldwide, is hard to diagnose at the point of care with patients often exhibiting no clinical symptoms. There is an urgent need for rapid point-of-care diagnostics to enable timely intervention. We have developed a technology for rapid acquisition of molecular fingerprints of TBI biochemistry to safely measure proxies for cerebral injury through the eye, providing a path toward noninvasive point-of-care neurodiagnostics using simultaneous Raman spectroscopy and fundus imaging of the neuroretina. Detection of endogenous neuromarkers in porcine eyes' posterior revealed enhancement of high-wave number bands, clearly distinguishing TBI and healthy cohorts, classified via artificial neural network algorithm for automated data interpretation. Clinically, translating into reduced specialist support, this markedly improves the speed of diagnosis. Designed as a hand-held cost-effective technology, it can allow clinicians to rapidly assess TBI at the point of care and identify long-term changes in brain biochemistry in acute or chronic neurodiseases.
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Date
2023-11-15
Type
Article
Subject
Neurology, Practice of medicine
Collections
Citation
Banbury C, Harris G, Clancy M, Blanch RJ, Rickard JJS, Goldberg Oppenheimer P. Window into the mind: Advanced handheld spectroscopic eye-safe technology for point-of-care neurodiagnostic. Sci Adv. 2023 Nov 17;9(46):eadg5431. doi: 10.1126/sciadv.adg5431. Epub 2023 Nov 15. PMID: 37967190; PMCID: PMC10651125.
Journal / Source Title
Science Advances
DOI
10.1126/sciadv.adg5431
PMID
37967190
Publisher
American Association for the Advancement of Science
Publisher’s URL
https://www.science.org/doi/10.1126/sciadv.adg5431