Strategies to reduce relapse risk in patients undergoing allogeneic stem cell transplantation for acute myeloid leukaemia.
Kinsella, Francesca A M Maroto, Maria A L Loke, Justin Craddock, Charles
Kinsella, Francesca A M
Maroto, Maria A L
Loke, Justin
Craddock, Charles
Abstract
Allogeneic stem cell transplantation is a centrally important curative strategy in adults with acute myeloid leukaemia; however, relapse occurs in a significant proportion of patients and remains the leading cause of treatment failure. The prognosis for patients who relapse post-transplant remains poor, and the development of new strategies with the ability to reduce disease recurrence without increasing transplant toxicity remains a priority. In this review, within the context of our understanding of disease biology and the graft-versus-leukaemia (GVL) effect, we will discuss established, evolving and novel approaches for increasing remission rates, decreasing measurable residual disease pretransplant, future methods to augment the GVL effect and the opportunities for post-transplant maintenance. Future progress depends upon the development of innovative trials and networks, which will ensure the rapid assessment of emerging therapies in prospective clinical trials.
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Date
2024-04-11
Type
Article
Other
Other
Subject
Haematology
Collections
Citation
Kinsella FAM, Maroto MAL, Loke J, Craddock C. Strategies to reduce relapse risk in patients undergoing allogeneic stem cell transplantation for acute myeloid leukaemia. Br J Haematol. 2024 Jun;204(6):2173-2183. doi: 10.1111/bjh.19463. Epub 2024 Apr 11.
Journal / Source Title
British Journal of Haematology
DOI
10.1111/bjh.19463
PMID
38602216
Publisher
Wiley-Blackwell
Publisher’s URL
http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2141