Age-related differences in cerebrovascular responses to cognitive stimulation using a novel method
Beishon, L. C. Boadi, E. Williams, C. A. Chithiramohan, T. Barnes, S. C. Intharakham, K. Batterham, A. P. Haunton, V. J. Robinson, T. G. Panerai, R. B.
Beishon, L. C.
Boadi, E.
Williams, C. A.
Chithiramohan, T.
Barnes, S. C.
Intharakham, K.
Batterham, A. P.
Haunton, V. J.
Robinson, T. G.
Panerai, R. B.
Abstract
Aging is associated with a number of alterations to cerebrovascular function. We aimed to investigate the effect of age on cerebrovascular responses to cognitive stimulation using an objective two-parameter method.Previously derived from a large data-set (135 healthy participants) were applied to a task-activated dataset of 69 healthy participants in five different task conditions. Cumulative response rate (CRR) was calculated as the sum of responses across tasks and hemispheres.There was a significant effect of age (adjusted odds ratio: 1.02 (95% confidence interval: 1.01, 1.04), p = 0.016). There was also a significant effect of task (p = 0.002), but there was no significant interaction between age and task (p = 0.37). Increasing age was associated with increased CRR (adjusted odds ratio: 1.04 (95% confidence interval: 1.01, 1.07), p = 0.009).Using an objective two-parameter method, healthy older adults had increased cerebrovascular responses to cognitive testing.
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Beishon, L. C., Boadi, E., Williams, C. A., Chithiramohan, T., Barnes, S. C., Intharakham, K., Batterham, A. P., Haunton, V. J., Robinson, T. G., & Panerai, R. B. (2022). Age-related differences in cerebrovascular responses to cognitive stimulation using a novel method. Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 29(6), 929–942. https://doi.org/10.1080/13825585.2021.1934387