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Alpha-Stim AID Cranial Electrotherapy Stimulation (CES) anxiety and depression treatment for adults in a social prescribing service: anxiety and depression outcomes

Griffiths, Chris
Smart, David
Galvin, Sinead
Macmillan, Helen
Terry, Debbie
Jiang, Harmony
Walker, Kate
Abstract
Background: Generalised anxiety disorder (GAD) is common and can negatively impact people’s wellbeing and functioning. GAD treatment includes psychotherapy and/or anti-anxiety medication, which are not acceptable to or effective for many people experiencing GAD. Alpha-Stim AID cranial electrotherapy stimulation (CES) has evidence of effectiveness in the treatment of anxiety and depression. Purpose: Evaluation of Alpha-Stim AID on anxiety and depression for adults with GAD symptoms using a social prescribing service. Methods: An open-label patient cohort design with no control group. Twenty-six adult patients, 22 females and 4 males, with an age range of 24 to 68 years and an average age of 49 years, completed 6 weeks of Alpha-Stim AID use. Pre- and post-intervention assessments were undertaken using participant self-report measures: Generalised Anxiety Disorder (GAD-7) and Patient Health Questionnaire (PHQ-9). Results: Reliable improvement and remission rates were 42% and 19% for GAD-7; 38% and 27% for PHQ-9. GAD-7 and PHQ-9 significantly improved with large effect sizes. Conclusions: A social prescribing service can offer, and patients will choose to use Alpha-Stim AID, which may be useful in the treatment of anxiety and depression. This study addresses the need for real-world data on Alpha-Stim AID in relation to response rates. It contributes to how Alpha-Stim Aid can be used in social prescribing services, including through a group-based pathway.
Citation
Griffiths, C., Smart, D., Galvin, S., Macmillan, H., Terry, D., Jiang, H., & Walker, K. (2025) Alpha-Stim AID Cranial Electrotherapy Stimulation (CES) Anxiety and Depression Treatment for Adults in a Social Prescribing Service: Anxiety and Depression Outcomes. Open Journal of Depression, 14, 1-12. doi: 10.4236/ojd.2025.141001
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Copyright © 2025 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/
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