The neuropsychiatric effects of nitrous oxide and low vitamin B12
Abstract
This narrative review article aims to update knowledge on the neuropsychiatric complications of nitrous oxide use and low vitamin B12. We consider common forms and uses of nitrous oxide (N2O) and review its mechanism of action, and then explore the potential impacts of use. In particular, neuropsychiatric effects mediated by low vitamin B12 are considered and the correct interpretation of laboratory results explored. This is of particular importance as where vitamin B12 is inactivated by chronic nitrous oxide use, blood test levels of vitamin B12 may not reflect the quantity of functional B12 in patients.
Citations
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Date
2021-09-30
Type
Article
Subject
Pharmacology
Collections
Citation
Farmer J, Romain K, Ibrahim M, Kumar M, York Moore W. The neuropsychiatric effects of nitrous oxide and low vitamin B12. BJPsych Advances. 2022;28(4):216-225. doi:10.1192/bja.2021.55
Journal / Source Title
BJPsych Advances
DOI
10.1192/bja.2021.55
PMID
Publisher
Cambridge University Press
Publisher’s URL
https://www.cambridge.org/core/journals/bjpsych-advances/article/neuropsychiatric-effects-of-nitrous-oxide-and-low-vitamin-b12/74CD7056C22ED060727FC3F126F565DA