Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England.
Freeman, Karoline Jenkinson, David Clements, Karen Wallis, Matthew G Pinder, Sarah E Provenzano, Elena Stobart, Hilary Stallard, Nigel Kearins, Olive Sharma, Nisha
Freeman, Karoline
Jenkinson, David
Clements, Karen
Wallis, Matthew G
Pinder, Sarah E
Provenzano, Elena
Stobart, Hilary
Stallard, Nigel
Kearins, Olive
Sharma, Nisha
Abstract
There was a fourfold increase in detection of atypia after the introduction of digital mammography between 2010 (n=119) and 2015 (n=502). During 19 088 person years of follow-up after atypia diagnosis (until December 2018), 141 women developed breast cancer. Cumulative incidence of cancer per 1000 women with atypia was 0.95 (95% confidence interval 0.28 to 2.69), 14.2 (10.3 to 19.1), and 45.0 (36.3 to 55.1) at one, three, and six years after atypia diagnosis, respectively. Women with atypia detected more recently have lower rates of subsequent cancers detected within three years (6.0 invasive cancers per 1000 women (95% confidence interval 3.1 to 10.9) in 2013-18 v 24.3 (13.7 to 40.1) in 2003-07, and 24.6 (14.9 to 38.3) in 2008-12). Grade, size, and nodal involvement of subsequent invasive cancers were similar to those of cancers detected in the general screening population, with equal numbers of ipsilateral and contralateral cancers.
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Date
2024-02-01
Type
Article
Subject
Gynaecology, Oncology. Pathology.
Collections
Citation
Freeman K, Jenkinson D, Clements K, Wallis MG, Pinder SE, Provenzano E, Stobart H, Stallard N, Kearins O, Sharma N, Shaaban A, Kirwan CC, Hilton B, Thompson AM, Taylor-Phillips S; Sloane Project Steering Group. Atypia detected during breast screening and subsequent development of cancer: observational analysis of the Sloane atypia prospective cohort in England. BMJ. 2024 Feb 1;384:e077039. doi: 10.1136/bmj-2023-077039.
Journal / Source Title
BMJ
DOI
10.1136/bmj-2023-077039
PMID
38302129
Publisher
British Medical Association
Publisher’s URL
http://www.bmj.com/thebmj