Large animal model of vein grafts intimal hyperplasia: A systematic review
Fashina, Oluwatomini Abbasciano, Riccardo McQueen, Liam Ladak, Shameem Zakkar, Mustafa
Fashina, Oluwatomini
Abbasciano, Riccardo
McQueen, Liam
Ladak, Shameem
Zakkar, Mustafa
Abstract
Coronary artery bypass grafting remains the treatment of choice for a large cohort of patients with significant coronary disease. Despite the increased use of arterial grafts, the long saphenous vein remains the most commonly used conduit. Long-term graft patency continues to be the Achilles heel of saphenous vein grafts. This is due to the development of intimal hyperplasia, a chronic inflammatory disease that results in the narrowing and occlusion of a significant number of vein grafts. Research models for intimal hyperplasia are essential for a better understanding of pathophysiological processes of this condition. Large animal models resemble human anatomical structures and have been used as a surrogate to study disease development and prevention over the years. In this paper, we systematically review all published studies that utilized large animal models of vein graft disease with a focus on the type of model and any therapeutic intervention, specifically the use of external stents/mesh.
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Date
2022-05-27
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Fashina, O., Abbasciano, R. G., McQueen, L. W., Ladak, S., George, S. J., Suleiman, S., Punjabi, P. P., Angelini, G. D., & Zakkar, M. (2022). Large animal model of vein grafts intimal hyperplasia: A systematic review. Perfusion, 2676591221091200. Advance online publication. https://doi.org/10.1177/02676591221091200